DMSA chelation during co-exposure to lead: increased locomotor activity in lead-exposed mice but not controls
| Autor: | Richard G. Burright, Peter J. Donovick, Paul W. Stewart |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Lead increased Experimental and Cognitive Psychology Motor Activity Locomotor activity Toxicology Behavioral Neuroscience Mice Internal medicine medicine Organometallic Compounds Ingestion Neurotoxin Animals Chelation Swimming business.industry Lead Poisoning Endocrinology Lead acetate Dimercaptosuccinic acid Lead exposure Exploratory Behavior business Arousal Succimer medicine.drug |
| Zdroj: | Physiologybehavior. 57(5) |
| ISSN: | 0031-9384 |
| Popis: | We investigated the effect of chelating agent meso-2,3 dimercaptosuccinic acid (DMSA) on indices of "hyperactive" behavior in lead-exposed and control Binghamton Heterogeneous Stock (Het) mice. As expected, 6 weeks of ingestion of 0.5% lead acetate in drinking water reduced immobility in a forced water swim relative to controls. DMSA did not attenuate this behavioral change. In fact, DMSA interacted with lead exposure to increase locomotor activity in the forced water swim. DMSA also apparently excacerbated lead's tendency to reduce immobility. While any generalizations to human populations should be cautioned, these results and others suggest the need for further research. |
| Databáze: | OpenAIRE |
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