Dysplasia features of myelodysplastic syndrome in ethnically Chinese people
Autor: | Xin Y Liu, Ping Zou, Wan X Chen, Ze H Tang, Qing F Yue, Bei Xiong |
---|---|
Rok vydání: | 2012 |
Předmět: |
Adult
Male China Adolescent Anemia Megaloblastic Anemia Neutrophils Hemoglobinuria Paroxysmal Cell Count Cell morphology Infections Giant Cells Autoimmune Diseases Young Adult Asian People Erythroid Cells Bone Marrow hemic and lymphatic diseases medicine Humans Cell Lineage Myeloid Cells Aplastic anemia Megaloblastic anemia Aged Cell Size Aged 80 and over Purpura Thrombocytopenic Idiopathic Staining and Labeling business.industry Hematology General Medicine Middle Aged medicine.disease Thrombocytopenic purpura Dysplasia Myelodysplastic Syndromes Immunology Paroxysmal nocturnal hemoglobinuria Hemoglobinuria Female business Megakaryocytes Prussian Blue Reaction |
Zdroj: | Acta haematologica. 131(2) |
ISSN: | 1421-9662 |
Popis: | Objective: It was our aim to study the diagnostic significances of various dysplasia characteristics in myelodysplastic syndrome (MDS). Methods: We analyzed 160 cases of primary MDS and a control group including 28 cases of paroxysmal nocturnal hemoglobinuria (PNH), 104 cases of idiopathic thrombocytopenic purpura (ITP), 53 cases of non-severe aplastic anemia (NSAA), 40 cases of megaloblastic anemia and 50 cases of infectious and autoimmune diseases. Peripheral blood smears and bone marrow morphology were reviewed. Results: There was no significant difference in the occurrence rates of a variety of dysplasias in three lineages among MDS, megaloblastic anemia and PNH; however, changes in qualities and quantities in three lineages between NSAA and MDS were significantly different. ITP and MDS showed statistical differences in multiple changes in myeloid and erythroid cells. Significant differences also existed in multiple changes in erythroid series and megakaryocytes between infectious and autoimmune diseases and MDS. Morphological abnormalities highly related with MDS included multinucleated erythroblasts, ringed sideroblasts, poikilocytosis and gigantocytes, pseudo-Pelger neutrophils, ring-shaped nucleus, and micromegakaryocytes. Conclusions: It is difficult to discriminate megaloblastic anemia and PNH from MDS by means of cell morphology. Different dysplasias of MDS have specific diagnostic values. |
Databáze: | OpenAIRE |
Externí odkaz: |