Full-field flicker evoked changes in parafoveal retinal blood flow
| Autor: | Tom Gast, Kaitlyn Sapoznik, Alberto de Castro, Stephen A. Burns, Raymond Luval Warner, Lucie Sawides, Ting Luo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Retinal blood flow genetic structures Retinal Artery lcsh:Medicine Stimulation Stimulus (physiology) Article Retina Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology Laser-Doppler Flowmetry Humans Medicine lcsh:Science Multidisciplinary business.industry Flicker lcsh:R Hemodynamics Retinal Vessels Retinal Full field Oxygen Vasodilation Arterioles Red blood cell medicine.anatomical_structure Optics and photonics chemistry Regional Blood Flow 030221 ophthalmology & optometry Neurovascular Coupling Female lcsh:Q business Blood Flow Velocity Photic Stimulation 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | When retinal activity is increased by exposure to dynamic visual stimuli, blood vessels dilate and the flow of blood within vessels increases to meet the oxygen and glucose demands of the neurons. This relationship is termed ‘neurovascular coupling’ and it is critical for regulating control of the human retinal vasculature. In this study, we used a recently developed technique based on a dual-beam adaptive optics scanning laser ophthalmoscope to measure changes in red blood cell velocities, vessel diameter, and flow in interconnected small parafoveal retinal vessels (t-test showed significant increases in velocity and flow in arterioles and venules. These measurements indicate that the mechanism of neurovascular coupling systematically affects the vascular response in small retinal vessels in order to maintain hemodynamic regulation in the retina when exposed to visual stimulation, in our case flicker. Our findings may provide insight into future investigations on the impairments of neurovascular coupling from vascular diseases such as diabetic mellitus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |