Toxicity effects of profenofos on embryonic and larval development of Zebrafish (Danio rerio)
| Autor: | M.S. Bethu, B. Yashwanth, Rajesh Pamanji, K. Ravinder, S. Leelavathi, J. Venkateswara Rao |
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| Rok vydání: | 2015 |
| Předmět: |
Heart Defects
Congenital Tail Insecticides Embryo Nonmammalian animal structures Health Toxicology and Mutagenesis Developmental toxicity Danio Embryonic Development Motor Activity Toxicology Andrology chemistry.chemical_compound Human fertilization Animals Zebrafish Yolk Sac Pharmacology Behavior Animal biology Hatching Organothiophosphates Embryo General Medicine biology.organism_classification Acetylcholinesterase Adipose Tissue chemistry Toxicity Cholinesterase Inhibitors Head |
| Zdroj: | Environmental Toxicology and Pharmacology. 39:887-897 |
| ISSN: | 1382-6689 |
| Popis: | The aim of the present study was to evaluate the developmental toxicity of profenofos to early developing Zebrafish (Danio rerio) embryos (4h post fertilization) in a static system at 1.0 to 2.25mg/L. Median lethal concentrations (LC50) of profenofos at 24-h, 48-h, 72-h and 96-h were determined as 2.04, 1.58, 1.57 and 1.56 mg/L, respectively. The hatching of embryos were recorded at every 12h interval and the median hatching time (HT50) was also calculated for each concentration. In a separate set of experiments, 96-h LC10 (0.74 mg/L) and LC50 (1.56 mg/L) concentrations were used to assess the developmental toxicity in relation to behavior, morphology, and interactions with the targeted enzyme acetylcholinesterase. Live video-microscopy revealed that the profenofos exposed embryos exhibited an abnormal development, skeletal defects and altered heart morphology in a concentration-dependent manner, which leads to alterations in the swimming behavior of hatchlings at 144-h, which indicate that developing zebrafish are sensitive to profenofos. |
| Databáze: | OpenAIRE |
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