Influence of concomitant miso or NaCl treatment on induction of gastric tumors by N-methyl-N'-nitro-N-nitrosoguanidine in rats
| Autor: | Y Ishimura, Shitau Hirata, Toshihiro Uesaka, Ken Kuramoto, Hiromitsu Watanabe, K Shiraki, Shuneki Shoji, S Kido, Osamu Katoh, Nariaki Fujimoto |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Methylnitronitrosoguanidine Sodium chemistry.chemical_element Biology Rats Sprague-Dawley Stomach Neoplasms Internal medicine medicine Animals Anticarcinogenic Agents Gastric tumor Glandular stomach Sodium Chloride Dietary N-Methyl-N'-nitro-N-nitrosoguanidine Stomach General Medicine medicine.disease Diet Rats Endocrinology medicine.anatomical_structure Oncology chemistry Apoptosis Concomitant Carcinogens Adenocarcinoma Soybeans |
| Zdroj: | Oncology reports. 6(5) |
| ISSN: | 1021-335X |
| Popis: | Six-week old male Sprague-Dawley (CD) rats were treated with 100 ppm N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for 16 weeks in their drinking water with control, miso or sodium chloride (NaCl) supplemented diets. All animals were autopsied 12 months after the beginning of the MNNG treatment. Despite higher intake of MNNG in the high dose miso and NaCl groups, the total tumor incidences were decreased compared to middle and lowest values. The glandular stomach adenocarcinoma incidences in the 10% and 5% miso groups were significantly decreased as compared to those in the 2.2% or 1.1% NaCl groups, with the same concentration of NaCl. |
| Databáze: | OpenAIRE |
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