Prospective randomized crossover trial comparing fibre with lactulose in the treatment of idiopathic chronic constipation
| Autor: | Kok-Sun Ho, Francis Seow-Choen, H. M. Quah, K. K. Sng, B. S. Ooi |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Constipation Adolescent medicine.medical_treatment Laxative Gastroenterology Citric Acid law.invention Lactulose Randomized controlled trial Gastrointestinal Agents law Internal medicine medicine Humans Prospective Studies Prospective cohort study Aged Aged 80 and over Chronic constipation Cross-Over Studies business.industry Plant Extracts Middle Aged Crossover study Surgery Drug Combinations Sodium Bicarbonate Treatment Outcome Tolerability Patient Satisfaction Chronic Disease Female medicine.symptom business medicine.drug |
| Zdroj: | Techniques in coloproctology. 10(2) |
| ISSN: | 1123-6337 |
| Popis: | Fibre is often recommended as the first-choice treatment but its effects can be uneven. The aim of the study was to compare the clinical efficacy and tolerability of fibre versus lactulose in outpatients with chronic constipation. In a prospective randomized crossover trial, patients were randomized to receive fibre or lactulose for four weeks. Between treatments, patients had at least one week free of laxatives. 50 patients, of median age 50 years (range, 18–85) were recruited and 39 patients completed the trial. Compared to fibre, lactulose resulted in significantly higher mean bowel frequency (7.3, 95% CI 5.7 to 8.9 vs. 5.5, 95% CI 4.4 to 6.5; p=0.001) and stool consistency score (3.4, 95% CI 3.1 to 3.7 vs. 2.9, 95% CI 2.5 to 3.3; p=0.018). Scores for ease of evacuation were similar. The frequencies of adverse effects were not significantly different, but greater in the lactulose group. Mean patients’ recorded improvement score was significantly higher after taking lactulose than fibre (6.2, 95% CI 5.5 to 7.0 vs. 4.8, 95% CI 4.0 to 5.9; p=0.017). Of the 39 patients who completed the trial, 24 (61.5%) preferred lactulose and 14 (35.9%) preferred fibre. Lactulose had better efficacy than fibre for chronic constipation in ambulant patients, although both treatments were equally well tolerated in terms of adverse effects. |
| Databáze: | OpenAIRE |
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