Alemtuzumab Induction Is Associated With an Equalization of Outcomes Between White and African American Kidney Transplant Recipients
| Autor: | Graham Mitro, Jorge Ortiz, Michael A. Rees, Anthony DeLeonibus, Weikai Qu, Munier Nazzal, Joseph T. Brooks |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Time Factors Allograft failure Delayed Graft Function Risk Assessment Kidney transplant White People Risk Factors Internal medicine medicine Humans Alemtuzumab Aged Retrospective Studies African american Transplantation Kidney business.industry Graft Survival Retrospective cohort study Patient survival Middle Aged Kidney Transplantation Transplant Recipients Black or African American Treatment Outcome surgical procedures operative medicine.anatomical_structure Female business Immunosuppressive Agents medicine.drug |
| Zdroj: | Experimental and Clinical Transplantation. 17:196-201 |
| ISSN: | 1304-0855 |
| Popis: | Objectives Our aim was to assess outcomes in White and African American kidney transplant recipients after induction with alemtuzumab. Materials and methods We performed a retrospective study of 464 patients who received deceased-donor kidney transplants and were induced with alem-tuzumab between March 2006 and May 2015. We evaluated ethnic influences on patient and graft survival, delayed graft function, allograft failure, and rejection. Results There were 337 White (67.3%) and 127 African American (25.3%) patients. We observed no significant differences in 1-, 3-, 5-, and 7- year death-censored graft survival. We also observed no significant differences in 1-, 3-, and 5-year patient survival rates. Having African American ethnicity was not a significant predictor of rejection, graft survival, or patient survival. Conclusions Our results indicate that recipient ethnicity is not a predictor of rejection, graft survival, or patient survival. White and African American kidney transplant recipients induced with alemtuzumab experienced an equalization of outcomes. |
| Databáze: | OpenAIRE |
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