Dissolution Profile Determination of a Multicomponent Product Using a Rapid Liquid Chromatographic Analysis
| Autor: | Dennis Adair, Richard A. Soltero, John Robinson |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Chromatography
Tandem Chemistry Chemistry Pharmaceutical Active components Analytical chemistry Pharmaceutical Science High-performance liquid chromatography Drug Combinations Hydrochlorothiazide Uv spectra Investigation methods Solubility Product (mathematics) Combination Product Spectrophotometry Ultraviolet Dissolution Chromatography High Pressure Liquid Metoprolol |
| Zdroj: | Journal of Pharmaceutical Sciences. 73:799-803 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600730623 |
| Popis: | A system was developed which is capable of monitoring the dissolution profiles of each of the active components in a two-component combination product. The UV spectra of the two drugs (metoprolol and hydro-chlorothiazide) overlap considerably, making conventional UV analysis of either component unrealistic. By resolving the two drugs on a high-performance liquid chromatographic (HPLC) system both can be quantitated after separation. The analysis is sufficiently short to allow for the use of a six-station dissolution tester in tandem with an HPLC for determination of dissolution profiles. The HPLC system and equipment, can monitor six samples of this product at 5-min intervals in real analysis time. |
| Databáze: | OpenAIRE |
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