Pea3 transcription factor promotes neurite outgrowth
| Autor: | Berrak Caglayan, Melis Savasan Sogut, Ozlem Demir, Ugur Dag, Burcu Erdogan, Isil Aksan Kurnaz, Başak Kandemir, Barbara Hausott, Lars Klimaschewski |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Nervous system
Subfamily Neurofilament Neurite Biology neurofilaments lcsh:RC321-571 Serine 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine medicine Original Research Article Transcription factor lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Molecular Biology 030304 developmental biology 0303 health sciences phosphorylation Regeneration (biology) Pea3 neuron body regions medicine.anatomical_structure axonal outgrowth Neuroscience 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Frontiers in Molecular Neuroscience Frontiers in Molecular Neuroscience, Vol 7 (2014) |
| ISSN: | 1662-5099 |
| DOI: | 10.3389/fnmol.2014.00059 |
| Popis: | Pea3 subfamily of E-twenty six transcription factors consist of three major -exhibit branching morphogenesis, the function of Pea3 family in nervous system development and regeneration is only beginning to unfold. In this study, we provide evidence that Pea3 can directs neurite extension and axonal outgrowth in different model systems, and that Serine 90 is important for this function. We have also identified neurofilament-L and neurofilament-M as two putative novel targets for Pea3. Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) Brain Research Society BAD-Lundbeck Project Award Turkish Academy of Science |
| Databáze: | OpenAIRE |
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