Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients

Autor:	Marie Helene Delbouille, Arnaud Ancion, Philippe Amabili, Jean-Olivier Defraigne, Melissa Van den Bulck, Vincent Tchana-Sato, Jean-Paul Lavigne, Philippe Delvenne, Elie Minga Lowampa, Marie-Pierre Hayette, Olivier Hougrand, Delphine Szecel, Isabelle Maquoi, Marc Senard, Charlotte Ponte, Julien Tridetti, Philippe Morimont, Natzi Sakalihasan, Olivier Detry, Patrizio Lancellotti
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Male medicine.medical_specialty medicine.medical_treatment Disease Comorbidity 030204 cardiovascular system & hematology 030230 surgery Heart transplantation Antiviral Agents Mycophenolic acid lcsh:Infectious and parasitic diseases 03 medical and health sciences Antimalarials Immunocompromised Host 0302 clinical medicine Medical microbiology Case report medicine Humans lcsh:RC109-216 Asymptomatic carrier Intensive care medicine business.industry SARS-CoV-2 COVID-19 Hydroxychloroquine Perioperative Middle Aged Mycophenolic Acid medicine.disease Transplant Recipients Coronavirus disease 2019 (COVID-19) Infectious Diseases Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) Female business medicine.drug
Zdroj:	BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-10 (2021) BMC Infectious Diseases
ISSN:	1471-2334
Popis:	Background There are limited data on Coronavirus disease 2019 (COVID-19) in solid organ transplant patients, especially in heart transplant recipients, with only a few case reports and case series described so far. Heart transplant recipients may be at particular high risk due to their comorbidities and immunosuppressed state. Case presentation This report describes the clinical course and the challenging management of early COVID-19 infection in two heart transplant recipients who tested positive for the SARS-CoV-2 virus in the perioperative period of the transplant procedure. The two patients developed a severe form of the disease and ultimately died despite the initiation of an antiviral monotherapy with hydroxychloroquine coupled with the interruption of mycophenolate mofetil. Conclusions These two cases illustrate the severity and poor prognosis of COVID-19 in the perioperative period of a heart transplant. Thorough screening of donors and recipients is mandatory, and the issue of asymptomatic carriers needs to be addressed.
Databáze:	OpenAIRE
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