The effect of age on plasma level of setiptiline maleate in depressed patients
| Autor: | Sakai Takashi, Kamimura Makoto, Aoba Annri, Chishima Tatsuo, Yamaguchi Noboru, Negishi Kyoichiro, Tsuneizumi Tomohiro, Kishiro Masaki, Takagi Hiroyuki, Hasegawa Kazuo, Morokawa Yumiyo, Takeshita Takashi, Ohta Tomoo |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Aging Mianserin Body weight Gas Chromatography-Mass Spectrometry chemistry.chemical_compound Pharmacokinetics Oral administration Internal medicine Blood plasma Medicine Humans Pharmacology (medical) Setiptiline Biological Psychiatry Aged Pharmacology Aged 80 and over Depressive Disorder Sex Characteristics business.industry Curve analysis Plasma levels Middle Aged Antidepressive Agents Surgery Endocrinology chemistry Female Neurology (clinical) business Clearance |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 18(6) |
| ISSN: | 0278-5846 |
| Popis: | 1. 1. Setiptiline maleate (SPT) was administered orally to 45 subjects aged 22–86 years and steady state plasma levels were determined by mass fragment chromatography (GC-MF) to examine the effect of aging on those values. 2. 2. There was a significant correlation between the plasma levels and daily dose. However, there was a wide interindividual variability. 3. 3. Dose-corrected plasma level (DC-PL), or values corrected by dividing the plasma level by daily dose/body weight, was used as the systemic drug clearance parameter. 4. 4. DC-PL was compared among 7 age groups of the subjects distributed in 10-year-intavals. DC-PL showed no difference among groups of subjects between the > 29 years bracket to the 70 years bracket, but showed significantly higher values in those in the > 80 bracket compared to all age groups and subjects in the < 79 bracket. 5. 5. There was a significant correlation between the age of patients and DC-PL according to polynomial response curve analysis. Regression analysis yielded te equation y = −52.72 + 7.05 × −0.17 x2 + 0.01 x3 (n = 45, r = 0.49, p |
| Databáze: | OpenAIRE |
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