Diuretics in the Management of Cardiorenal Syndrome
| Autor: | Chandrika Chitturi, James E. Novak |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Volume overload Disease Cardiorenal syndrome 030204 cardiovascular system & hematology Risk Assessment Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Sodium Potassium Chloride Symporter Inhibitors medicine Humans 030212 general & internal medicine Intensive care medicine Cause of death Heart Failure Cardio-Renal Syndrome business.industry Acute Kidney Injury medicine.disease Prognosis Diuretic treatment Survival Analysis Treatment Outcome Nephrology Heart failure Disease Progression Diuretic business Kidney disease |
| Zdroj: | Advances in chronic kidney disease. 25(5) |
| ISSN: | 1548-5609 |
| Popis: | The leading cause of death worldwide is cardiovascular disease. The heart and the kidneys are functionally interdependent, such that dysfunction in one organ may cause dysfunction in the other. By one estimate, more than 60% of patients with congestive heart failure develop chronic kidney disease. Volume overload and congestion are hallmarks of heart failure, and these findings are associated with severe symptoms and poor outcomes. Given the importance of congestion, diuretics remain a cornerstone of heart failure management. However, diuretic treatment remains largely empirical, with little evidence currently available to guide decisions. In this review, we discuss the pathophysiology of cardiorenal syndrome, the pharmacology of loop diuretics, mechanisms of diuretic resistance, and evidence-based treatment paradigms. |
| Databáze: | OpenAIRE |
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