Genetic association of SLC2A14 polymorphism with Alzheimer's disease in a Han Chinese population
| Autor: | Wei Wang, Lan Tan, Jin-Tai Yu, Wei-Zhen Cui, Zhong-Chen Wu, Wei Zhang, Qun Zhang |
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| Rok vydání: | 2012 |
| Předmět: |
Apolipoprotein E
Male medicine.medical_specialty China Glucose Transport Proteins Facilitative Biology Cellular and Molecular Neuroscience Asian People Alzheimer Disease Internal medicine Genotype medicine Genetic predisposition SNP Humans Allele Allele frequency Genetic association Aged Genetics Aged 80 and over Polymorphism Genetic General Medicine Odds ratio Endocrinology Female |
| Zdroj: | Journal of molecular neuroscience : MN. 47(3) |
| ISSN: | 1559-1166 |
| Popis: | Glucose uptake and metabolism are impaired in Alzheimer’s disease (AD) brain, which appear to be a cause, rather than a consequence of neurodegeneration. Recently, the gene of the 14th isoform of subfamily A of solute carrier family 2 (SLC2A14), encoding glucose transporter 14 (GLUT14), was identified for the association in vivo with AD pathology of Tau, and rs10845990 within SLC2A14 showed association with AD in Caucasians. In order to evaluate the involvement of the SLC2A14 polymorphism in the risk of developing late-onset Alzheimer’s disease (LOAD) in Chinese, we performed an independent case–control association study in a Han Chinese population (597 LOAD cases and 605 healthy controls). There were significant differences in genotype and allele frequencies between LOAD cases and controls (genotype P = 0.015, allele P = 0.039). The G-carrying genotype (GT + GG) individuals showed a 1.41-fold increased risk compared with the TT genotype carriers (odds ratio (OR) = 1.41, 95 % confidence interval (CI) = 1.11–1.79, P = 0.005, Power = 83.6 %). After stratification by ApoE e4-carrying status, rs10845990 polymorphism was only significantly associated with LOAD in non-ApoE e4 allele carriers (P |
| Databáze: | OpenAIRE |
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