Chemoprevention of chemical-induced skin cancer by Panax ginseng root extract
| Autor: | Pradeep Kumar Goyal, Jyoti Sharma |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
media_common.quotation_subject
Population medicine.disease_cause complex mixtures Biochemistry Genetics and Molecular Biology (miscellaneous) chemical carcinogenesis Ginseng lcsh:Botany medicine chemoprevention oxidative stress education media_common education.field_of_study Traditional medicine business.industry Longevity Panax ginseng Cancer medicine.disease lcsh:QK1-989 Complementary and alternative medicine Cancer incidence Panax ginseng root extract Skin cancer business Carcinogenesis Biotechnology Research Article |
| Zdroj: | Journal of Ginseng Research Journal of Ginseng Research, Vol 39, Iss 3, Pp 265-273 (2015) |
| ISSN: | 1226-8453 |
| DOI: | 10.1016/j.jgr.2015.01.005 |
| Popis: | Background: Cancer has emerged as a major health problem globally as a consequence to the increased longevity of the population, changing the environment and life style. Chemoprevention is a new and promising strategy for reducing cancer burden. Recently, some natural products have been identified for their chemopreventive activity to reduce the cancer incidence. Ginseng is known for its potential to treat various ailments in human beings. The present study was designed to explore the anticancer and antioxidative potential of Panax ginseng against chemical-induced skin carcinogenesis in mammals. Methods: Skin tumors were induced in Swiss albino mice by a single topical application of 7,12-dimethylbenz(a)anthracene (100 μg/100 μL acetone) and, 2 wks later, promoted by repeated applications of croton oil (thrice in a wk in 1% acetone) till the end of the experiment (i.e., 16 wk). Hydroalcoholic ginseng root extract at a dose of 25 mg/kg body weight/d was orally administered at the peri-initiation, postinitiation, and peri–post-initiation stages. Results: Ginseng root extract treatment caused a significant reduction in tumor incidence, cumulative number of tumors, tumor yield, and tumor burden, as compared to the 7,12-dimethylbenz(a)anthracene–croton oil-treated control group. Further, biochemical assays revealed a significant enhancement in the levels of reduced glutathione, superoxide dismutase, catalase, vitamin C, and total proteins but a significant reduction in lipid peroxidation levels in both the liver and skin with ginseng root extract treatment, as compared to carcinogen-treated control group. Conclusion: These results suggest that P. ginseng has the potential to become a pivotal chemopreventive agent that can reduce cancer in mammals. |
| Databáze: | OpenAIRE |
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