Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery
| Autor: | María Antonieta Daza Millone, Cecilia Yamil Chain, José Sebastián Cisneros, Eduardo Alejandro Ramirez, María Elena Vela |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Mini Review Nanoparticle Nanotechnology 02 engineering and technology lipid nanoparticles 010402 general chemistry 01 natural sciences molecular target lcsh:Chemistry protein corona Surface plasmon resonance Ciencias Exactas Label free Física General Chemistry Química drug carriers Surface Plasmon Resonance 021001 nanoscience & nanotechnology Controlled release 0104 chemical sciences Characterization (materials science) Chemistry lcsh:QD1-999 Drug delivery 0210 nano-technology Drug carrier Biosensor |
| Zdroj: | SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP Frontiers in Chemistry Frontiers in Chemistry, Vol 8 (2021) |
| Popis: | The development of drug carriers based in lipid nanoparticles (LNPs) aims toward the synthesis of non-toxic multifunctional nanovehicles that can bypass the immune system and allow specific site targeting, controlled release and complete degradation of the carrier components. Among label free techniques, Surface Plasmon Resonance (SPR) biosensing is a versatile tool to study LNPs in the field of nanotherapeutics research. SPR, widely used for the analysis of molecular interactions, is based on the immobilization of one of the interacting partners to the sensor surface, which can be easily achieved in the case of LNPs by hydrophobic attachment onto commercial lipid- capture sensor chips. In the last years SPR technology has emerged as an interesting strategy for studying molecular aspects of drug delivery that determines the efficacy of the nanotherapeutical such as LNPs' interactions with biological targets, with serum proteins and with tumor extracelullar matrix. Moreover, SPR has contributed to the obtention and characterization of LNPs, gathering information about the interplay between components of the formulations, their response to organic molecules and, more recently, the quantification and molecular characterization of exosomes. By the combination of available sensor platforms, assay quickness and straight forward platform adaptation for new carrier systems, SPR is becoming a high throughput technique for LNPs' characterization and analysis. Facultad de Ciencias Exactas Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas |
| Databáze: | OpenAIRE |
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