Granulocyte colony-stimulating factor-producing hepatocellular carcinoma with abrupt changes
| Autor: | Mitsuo Kishimoto, Hiroaki Nagata, Eigo Otsuji, Wataru Takaki, Hiroshi Konosu, Shuhei Komatsu, Tokunari Okayama, Michiaki Ishii, Yasunori Sawabe |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Hepatocellular carcinoma medicine.medical_treatment Sarcomatous changes Granulocyte 03 medical and health sciences 0302 clinical medicine Poorly Differentiated Hepatocellular Carcinoma White blood cell medicine Radical surgery business.industry Cancer Minireviews medicine.disease Immunohistochemistry Granulocyte colony-stimulating factor medicine.anatomical_structure Oncology Granulocyte colony-stimulating factor producing tumor 030220 oncology & carcinogenesis Granulocyte colony stimulating factor 030211 gastroenterology & hepatology Hepatectomy business |
| Zdroj: | World Journal of Clinical Oncology |
| ISSN: | 2218-4333 |
| Popis: | Granulocyte colony-stimulating factor (G-CSF)-producing tumor is one of the rare types of cancer clinically characterized by an elevated fever and white blood cell (WBC) increment. Although G-CSF producing tumors have been reported in several types of cancer including those of the lungs, cervix and bladder, G-CSF producing hepatocellular carcinoma is extremely rare. Here, we report the case of a rapidly growing and poorly differentiated hepatocellular carcinoma producing G-CSF. The patient showed symptoms of continuous high fever, stomach pain and cough, and high serum WBC counts, C-reactive protein (CRP) and G-CSF levels were found in laboratory tests. After a radical hepatectomy, the patient completely recovered from the above symptoms and inflammatory state. The serum levels of G-CSF were reduced to normal levels after radical surgery. An immunohistochemical analysis revealed the overexpression of G-CSF in the cytoplasm of certain hepatocellular carcinoma (HCC) cell. The patient's serum WBC, CRP and G-CSF levels remained within normal levels in the six months after surgery without recurrence. This is the 9th case report of G-CSF producing hepatocellular carcinoma in English literature. We review the clinical characteristics of the G-CSF producing HCC and discuss a possible treatment strategy. |
| Databáze: | OpenAIRE |
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