Extended data for 'ANCA-associated vasculitis in Ireland: a multi-centre national cohort study'

Autor: Scott, Jennifer, Nic an Ríogh, Eithne, Al Nokhatha, Shamma, Cowhig, Cliona, Verrelli, Alyssa, Fitzgerald, Ted, White, Arthur, Walsh, Cathal, Aslett, Louis, DeFreitas, Declan, Clarkson, Michael R., Holian, John, Griffin, Matthew D., Conlon, Niall, O'Meara, Yvonne, Casserly, Liam, Molloy, Eamonn, Power, Julie, Moran, Sarah M., Little, Mark A.
Jazyk: angličtina
Rok vydání: 2022
Předmět:
DOI: 10.5281/zenodo.7342933
Popis: Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare multisystem autoimmune disease. There is a need for interoperable national registries to enable reporting of real-world long-term outcomes and their predictors in AAV. Methods: The Irish National Rare Kidney Disease (RKD) registry was founded in 2012. To date, 842 patients with various forms of vasculitis have been recruited across eight nephrology, rheumatology and immunology centres. We focus here on patient- and disease- characteristics, treatment and outcomes of the 397 prospectively recruited patients with AAV. Results: Median age was 64 years (IQR 55–73), 57.9% were male, 58.9% had microscopic polyangiitis and 85.9% had renal impairment. Cumulative one- and five-year patient survival was 94% and 77% respectively. Median follow-up was 33.5 months (IQR 10.7–52.7). After controlling for age, baseline renal dysfunction (p = 0.04) and the burden of adverse events (p
Grant information: Health Research Board and Wellcome [203930/B/16/Z], the Health Service Executive, National Doctors Training and Planning and the Health and Social Care, Research and Development Division, Northern Ireland supports the Irish Clinical Academic Training (ICAT) Programme, of which Dr Jennifer Scott is a Wellcome-HRB Irish Clinical Academic Training (ICAT) Fellow. MAL received funding from Health Research Board / Irish Nephrology Society (MRCG-2016-12) and from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 813545.
Databáze: OpenAIRE
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