A model of Staphylococcus aureus bacteremia, septic arthritis, and osteomyelitis in chickens
| Autor: | R S Daum, R J Campeau, W H Davis, K B Farris, S M Shane, D M Mulvihill |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Micrococcaceae Time Factors Arthritis Technetium Tc 99m Medronate medicine.disease_cause Bone and Bones Microbiology Sepsis medicine Synovial fluid Animals Orthopedics and Sports Medicine Radionuclide Imaging biology business.industry Osteomyelitis Staphylococcal Infections medicine.disease biology.organism_classification Radiography Disease Models Animal Staphylococcus aureus Bacteremia Septic arthritis Osteitis business Chickens |
| Zdroj: | Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 8(6) |
| ISSN: | 0736-0266 |
| Popis: | We studied the occurrence, magnitude, and kinetics of bacteremia and the resultant osteomyelitis and septic arthritis in an avian model of Staphylococcus aureus infection. Thirty-day-old male broiler chicks were inoculated i.v. with 10(5), 10(6), or 10(7) cfu of strain Duntravis, a beta-hemolytic, coagulase-producing, capsular type 8 isolate from the synovial fluid of a 2-year-old black boy. Bacteremia occurred in 80%, 90%, and 100% of animals inoculated with 10(5), 10(6), or 10(7) cfu, respectively. The magnitude of bacteremia in surviving, bacteremic animals increased for 96 hours after inoculation and then decreased after a plateau phase. Osteomyelitis and septic arthritis occurred only in chicks that were continuously bacteremic. The occurrence of osteomyelitis was uniform among continuously bacteremic animals and developed 1 to 23 hours after inoculation. Chickens are susceptible to systemic infections with S. aureus. Bacteremia, osteomyelitis, and septic arthritis may be induced in healthy chickens without prior manipulations that depress their resistance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text