NBTXR3, a first-in-class radioenhancer for pancreatic ductal adenocarcinoma: Report of first patient experience
| Autor: | Bagley, Alexander F., Ludmir, Ethan B., Maitra, Anirban, Minsky, Bruce D., Li Smith, Grace, Das, Prajnan, Koong, Albert C., Holliday, Emma B., Taniguchi, Cullen M., Katz, Matthew H.G., Tamm, Eric P., Wolff, Robert A., Overman, Michael J., Patel, Shivani, Kim, Michael P., Tzeng, Ching-Wei D., Ikoma, Naruhiko, Bhutani, Manoop S., Koay, Eugene J. |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Clinical and Translational Radiation Oncology, Vol 33, Iss, Pp 66-69 (2022) Clinical and Translational Radiation Oncology |
| ISSN: | 2405-6308 |
| Popis: | Highlights • NBTXR3 is a radioenhancer composed of functionalized hafnium oxide nanoparticles. • This report describes the first patient with pancreatic cancer treated with NBTXR3. • First demonstration of local endoscopic delivery of NBTXR3 to a deep visceral tumor. • Multidisciplinary care critical for treating pancreatic cancer patients with NBTXR3. Background and purpose Pancreatic ductal adenocarcinoma (PDAC) remains one of the leading causes of cancer-related deaths in the world. For patients with PDAC who are not eligible for surgery, radiation therapy improves local disease control, yet safely delivering therapeutic doses of radiation remains challenging due to off-target toxicities in surrounding normal tissues. NBTXR3, a novel radioenhancer composed of functionalized hafnium oxide crystalline nanoparticles, has recently shown clinical activity in soft tissue sarcoma, hepatocellular carcinoma, head and neck squamous cell carcinoma, and advanced solid malignancies with lung or liver metastases. Here we report the first patient with pancreatic cancer treated with NBTXR3. Materials and methods A 66-year-old male with unresectable locally advanced PDAC was enrolled on our clinical trial to receive NBTXR3 activated by radiation therapy. Local endoscopic delivery of NBTXR3 was followed by intensity modulated radiation therapy (IMRT). Follow-up assessment consisted of physical examination, laboratory studies including CA19-9, and CT of the chest, abdomen, and pelvis. Results The patient received NBTXR3 by local endoscopic delivery without any acute adverse events. Radiation treatment consisted of 45 Gy in 15 daily fractions using IMRT. The patient began radiation twelve days after NBTXR3 injection. Daily CT-on-rails imaging demonstrated retention of NBTXR3 within the tumor for the duration of treatment. At initial follow-up evaluation, the lesion remained radiographically stable and the patient did not demonstrate treatment-related toxicity. Conclusion This report demonstrates initial feasibility of local endoscopic delivery of NBTXR3 activated by radiation therapy for patients with pancreatic cancer who are not eligible for surgery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|