Renal nerve activity does not contribute to the development of renovascular hypertension in rats with abdominal aortic constriction
| Autor: | Anita Aperia, A.-C. Eklöf, Tomas Hökfelt |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Physiology Calcitonin Gene-Related Peptide Blood Pressure Constriction Pathologic Kidney urologic and male genital diseases Renovascular hypertension medicine.artery Internal medicine medicine Animals Neuropeptide Y Aorta Abdominal Neurons Afferent Renal artery Denervation Aorta business.industry Angiotensin II Sodium Rats Inbred Strains medicine.disease Rats Filtration fraction Hypertension Renovascular Endocrinology medicine.anatomical_structure Blood pressure cardiovascular system Cardiology business circulatory and respiratory physiology |
| Zdroj: | Acta Physiologica Scandinavica. 141:71-77 |
| ISSN: | 1365-201X 0001-6772 |
| DOI: | 10.1111/j.1748-1716.1991.tb09046.x |
| Popis: | This study examines the influence of renal nerves on the development of renovascular hypertension in proximal aortic constricted rats. The rats were studied 1 week after unilateral or bilateral denervation of the renal artery. Denervation had no effect on the increase in mean arterial pressure induced by the constriction. The glomerular filtration rate and filtration fraction in control and in proximal aortic constricted rats were not influenced by the denervation. The Na excretion was increased in the denervated kidney both in control and in proximal aortic constricted rats. Plasma angiotensin II levels were not different from controls in innervated or unilaterally denervated proximal aortic constricted rats. In bilaterally denervated proximal aortic constricted rats the plasma angiotensin II levels were significantly higher. The renovascular hypertension and the alteration in renal function in proximal aortic constricted rats are not dependent on renal nerve activity. |
| Databáze: | OpenAIRE |
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