Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer’s-like dementia: Involvement of acetylcholinesterase and cell death

Autor: Micheli M. Pillat, Stephen A. Adefegha, Jucimara Baldissarelli, Guilherme Lopes Dornelles, Fátima Husein Abdalla, Luana Pereira Magni, Cinthia Melazzo de Andrade, Taís Vidal Palma, Luana Suéling Lenz, Jamile da Silva Bernardi, Maribel Antonello Rubin, Juliana Sorraila de Oliveira, Cristiane Signor
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
Programmed cell death
Berberine
endocrine system diseases
Anxiety
Toxicology
Neuroprotection
Streptozocin
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Alzheimer Disease
Internal medicine
medicine
Animals
Hippocampus (mythology)
Rats
Wistar
Maze Learning
Memory Disorders
Antibiotics
Antineoplastic
Cell Death
Dose-Response Relationship
Drug
L-Lactate Dehydrogenase
business.industry
General Neuroscience
Body Weight
Brain
nutritional and metabolic diseases
Streptozotocin
Acetylcholinesterase
Rats
Disease Models
Animal
Neuroprotective Agents
030104 developmental biology
medicine.anatomical_structure
Endocrinology
chemistry
Anxiogenic
Cerebral cortex
Exploratory Behavior
sense organs
business
030217 neurology & neurosurgery
Synaptosomes
medicine.drug
Zdroj: NeuroToxicology. 57:241-250
ISSN: 0161-813X
DOI: 10.1016/j.neuro.2016.10.008
Popis: The present study aimed to investigate the effects of berberine (BRB) on spatial and learning memory, anxiety, acetylcholinesterase activity and cell death in an experimental model of intracerebroventricular streptozotocin (ICV-STZ) induced sporadic Alzheimer's-like dementia. Sixty male Wistar rats were randomly divided into six groups: control (CTR), BRB 50mg/kg (BRB 50), BRB 100mg/kg (BRB 100), streptozotocin (STZ), streptozotocin plus BRB 50mg/kg (STZ+BRB 50), and streptozotocin plus BRB 100mg/kg (STZ+BRB 100). Rats were injected with ICV-STZ (3mg/kg) or saline, and daily oral BRB treatment began on day 4 for a period of 21days. Behavioral tests were carried out on day 17, and rats were euthanized on day 24. Cell death analysis and determination of acetylcholinesterase activity was performed on the cerebral cortex and hippocampus of the brain. Administration of BRB prevented the memory loss, anxiogenic behavior, increased acetylcholinesterase activity and cell death induced by ICV-STZ. This may be explained, in part, by a protective effect of BRB on ameliorating the progression of neurodegenerative diseases, including Alzheimer's disease, and the results of this study provide a better understanding of the effect of BRB on the brain. Thus, BRB may act as a potential neuroprotective agent.
Databáze: OpenAIRE
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