Twelve‐month outcomes of patients unsuitable for prolonged DAPT presenting with an acute coronary syndrome and treated with polymer‐free biolimus A9 drug‐coated stents

Autor: Tim Kinnaird, Sean Gallagher, Peter O'Kane, Khaled Yazji, Ahmed Hailan, Azeem S Sheikh, Senthil Elangovan, Anirban Choudhury, Richard Anderson, Fairoz Abdul, Adnan Yousef, David J. Smith, Jonathan Hinton
Rok vydání: 2018
Předmět:
Male
medicine.medical_specialty
Acute coronary syndrome
Time Factors
medicine.medical_treatment
Hemorrhage
Coronary Artery Disease
030204 cardiovascular system & hematology
Prosthesis Design
Risk Assessment
Drug Administration Schedule
03 medical and health sciences
Percutaneous Coronary Intervention
0302 clinical medicine
Risk Factors
Humans
Medicine
Radiology
Nuclear Medicine and imaging

cardiovascular diseases
030212 general & internal medicine
Acute Coronary Syndrome
Aged
Retrospective Studies
Aged
80 and over

Sirolimus
Framingham Risk Score
business.industry
Vascular disease
Stent
Cardiovascular Agents
Drug-Eluting Stents
General Medicine
Middle Aged
medicine.disease
United Kingdom
Surgery
Treatment Outcome
surgical procedures
operative

Conventional PCI
Cohort
Drug Therapy
Combination

Female
Cardiology and Cardiovascular Medicine
business
Platelet Aggregation Inhibitors
Mace
Preliminary Data
Kidney disease
Zdroj: Catheterization and Cardiovascular Interventions. 92:1220-1228
ISSN: 1522-726X
1522-1946
DOI: 10.1002/ccd.27722
Popis: INTRODUCTION Prolonged dual anti-platelet therapy (DAPT) is undesirable in certain patients. The biolimus-A9 drug-coated stent (BA9-DCS) has a rapid drug-elution profile allowing shortened DAPT. METHODS The demographics, procedural data, and clinical outcomes for 505 patients presenting with an ACS to three UK centres and treated with a BA9-DCS stent (PCI-DCS) were collected, and compared to a consecutive ACS cohort of unselected patients treated in the same period with drug-eluting stents (PCI-DES). RESULTS PCI-DCS patients were older, more often female with hypertension, chronic kidney disease, severe LV dysfunction, and peripheral vascular disease more frequent than the PCI-DES cohort. PCI-DCS patients had a much higher Mehran bleed risk score (21.5 ± 7.7 vs. 15.9 ± 7.7, P
Databáze: OpenAIRE