Lung ultrasound B-lines and serum KL-6 correlate with the severity of idiopathic inflammatory myositis-associated interstitial lung disease

Autor: Xiufeng Huang, Daniel E. Furst, Shijian Hu, Jianqun Lin, Marco Matucci-Cerinic, Yukai Wang, Shaoqi Chen, Luna Gargani, Xuezhen Xie, Guohong Zhang, Qisheng Lin, Kedi Zheng, Guangzhou Du
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Vital capacity
030204 cardiovascular system & hematology
Positive correlation
Gastroenterology
pulmonary function tests
Severity of Illness Index
Pulmonary function testing
03 medical and health sciences
B-lines
0302 clinical medicine
Rheumatology
Internal medicine
medicine
high-resolution CT
Humans
Pharmacology (medical)
Lung volumes
Lung
Myositis
AcademicSubjects/MED00360
lung ultrasound
Ultrasonography
030203 arthritis & rheumatology
business.industry
KL-6
Mucin-1
Interstitial lung disease
respiratory system
Clinical Science
Middle Aged
medicine.disease
Lung ultrasound
respiratory tract diseases
Respiratory Function Tests
idiopathic inflammatory myositis-associated interstitial lung disease
Idiopathic inflammatory myositis
Female
business
Lung Diseases
Interstitial
Biomarkers
Zdroj: Rheumatology (Oxford, England)
ISSN: 1462-0332
1462-0324
Popis: Objective Idiopathic inflammatory myositis-associated interstitial lung disease (IIM-ILD) significantly increases morbidity and mortality. Lung ultrasound B-lines and Krebs von den Lungen-6 (KL-6) are identified as new sonographic and serum markers of ILD, respectively. The aim of our work was to assess the role of B-lines and KL-6 as markers of the severity of IIM-ILD. For this purpose, the correlation among B-lines score, serum KL-6 levels, high-resolution CT (HRCT) score, and pulmonary function tests were investigated in IIM-ILD patients. Methods Thirty-eight patients with IIM-ILD underwent chest HRCT scans, lung ultrasound and pulmonary function tests (independently performed within 1 week) examination. To assess severity and extent of ILD at HRCT, the Warrick score was used. The B-lines score denoting the extension of ILD was calculated by summing the number of B-lines on a total of 50 scanning sites. Serum KL-6 levels (U/ml) was measured by chemiluminescent enzyme immunoassay. Results A significant correlation was found between the B-lines score and serum KL-6 levels (r = 0.43, P Conclusion B-lines score and serum KL-6 levels correlate with HRCT findings and pulmonary function tests, supporting their use as measures of IIM-ILD severity.
Databáze: OpenAIRE
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