Lung ultrasound B-lines and serum KL-6 correlate with the severity of idiopathic inflammatory myositis-associated interstitial lung disease
Autor: | Xiufeng Huang, Daniel E. Furst, Shijian Hu, Jianqun Lin, Marco Matucci-Cerinic, Yukai Wang, Shaoqi Chen, Luna Gargani, Xuezhen Xie, Guohong Zhang, Qisheng Lin, Kedi Zheng, Guangzhou Du |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Adult
Male medicine.medical_specialty Vital capacity 030204 cardiovascular system & hematology Positive correlation Gastroenterology pulmonary function tests Severity of Illness Index Pulmonary function testing 03 medical and health sciences B-lines 0302 clinical medicine Rheumatology Internal medicine medicine high-resolution CT Humans Pharmacology (medical) Lung volumes Lung Myositis AcademicSubjects/MED00360 lung ultrasound Ultrasonography 030203 arthritis & rheumatology business.industry KL-6 Mucin-1 Interstitial lung disease respiratory system Clinical Science Middle Aged medicine.disease Lung ultrasound respiratory tract diseases Respiratory Function Tests idiopathic inflammatory myositis-associated interstitial lung disease Idiopathic inflammatory myositis Female business Lung Diseases Interstitial Biomarkers |
Zdroj: | Rheumatology (Oxford, England) |
ISSN: | 1462-0332 1462-0324 |
Popis: | Objective Idiopathic inflammatory myositis-associated interstitial lung disease (IIM-ILD) significantly increases morbidity and mortality. Lung ultrasound B-lines and Krebs von den Lungen-6 (KL-6) are identified as new sonographic and serum markers of ILD, respectively. The aim of our work was to assess the role of B-lines and KL-6 as markers of the severity of IIM-ILD. For this purpose, the correlation among B-lines score, serum KL-6 levels, high-resolution CT (HRCT) score, and pulmonary function tests were investigated in IIM-ILD patients. Methods Thirty-eight patients with IIM-ILD underwent chest HRCT scans, lung ultrasound and pulmonary function tests (independently performed within 1 week) examination. To assess severity and extent of ILD at HRCT, the Warrick score was used. The B-lines score denoting the extension of ILD was calculated by summing the number of B-lines on a total of 50 scanning sites. Serum KL-6 levels (U/ml) was measured by chemiluminescent enzyme immunoassay. Results A significant correlation was found between the B-lines score and serum KL-6 levels (r = 0.43, P Conclusion B-lines score and serum KL-6 levels correlate with HRCT findings and pulmonary function tests, supporting their use as measures of IIM-ILD severity. |
Databáze: | OpenAIRE |
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