Routine detection of serum anti-desmocollin autoantibodies is only useful in patients with atypical pemphigus
| Autor: | Inga M Dettmann, Marcel F. Jonkman, Sandrine Benoit, Christine Bangert, Takashi Hashimoto, Kristin Rentzsch, Christian Probst, Kai Fechner, Susanne Lemcke, Nina van Beek, Winfried Stöcker, Enno Schmidt, Ingolf Karl, Tarek Fuhrmann, Hendri H. Pas, Lars Komorowski, Swantje Mindorf, Miklós Sárdy, Stine Krüger, Detlef Zillikens |
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| Přispěvatelé: | Microbes in Health and Disease (MHD), Translational Immunology Groningen (TRIGR) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty diagnosis Dermatology Biochemistry Desmoglein Cohort Studies 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine immune system diseases medicine Journal Article Humans skin and connective tissue diseases Molecular Biology Pemphigus foliaceus Autoantibodies foliaceus integumentary system business.industry Pemphigus vulgaris Autoantibody medicine.disease Pemphigus HEK293 Cells 030104 developmental biology Paraneoplastic pemphigus atypical vulgaris vegetans Immunology Desmocollin Pemphigus vegetans business DESMOCOLLINS autoantibody |
| Zdroj: | Experimental dermatology, 26(12), 1267-1270. Blackwell Publishing Ltd |
| ISSN: | 0906-6705 |
| Popis: | Autoantibodies against the 3 desmocollin (Dsc; Dsc1-Dsc3) isoforms have been described in different pemphigus variants. Here, we developed state-of-the-art detection systems for serum anti-Dsc1, Dsc2 and Dsc1 IgG and IgA. These assays were applied in 5 different cohorts including pemphigus vulgaris (PV) patients with compatible direct immunofluorescence (IF) microscopy but no reactivity against desmogleins 1 and 3 (n = 24) and sera from patients with autoimmune blistering diseases with positive direct IF microscopy taken at the time of diagnosis (n = 749). We found that detection of anti-Dsc serum reactivity is not helpful in the routine diagnosis of PV, pemphigus foliaceus and paraneoplastic pemphigus but may be valuable in pemphigus vegetans. |
| Databáze: | OpenAIRE |
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