Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemia

Autor: Ibrahim Khider Ibrahim, Othman Saeed Bahashwan, Saadia Osman Abdelrahim, Salem Ahmed Bamusa, Eman Abbass Fadul, Enaam Abdelrhman Abdelgader, Ameen Abdulaziz Basabaeen, Nour Mahmoud Abdelateif, Osama Ali Altayeb, Ebtihal Ahmed Babekir
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
ZAP-70
lcsh:Medicine
Gene Expression
CD38
Gastroenterology
Sudan
Correlation
0302 clinical medicine
Medicine
Hematological
Prospective Studies
030212 general & internal medicine
Stage (cooking)
lcsh:QH301-705.5
B-Lymphocytes
Membrane Glycoproteins
ZAP-70 Protein-Tyrosine Kinase
Combined
hemic and immune systems
B-CLL
General Medicine
Middle Aged
Binet
Research Note
Cd38 expression
Female
Disease staging
Adult
medicine.medical_specialty
chemical and pharmacologic phenomena
General Biochemistry
Genetics and Molecular Biology
Immunophenotyping
03 medical and health sciences
Internal medicine
Biomarkers
Tumor
Humans
B-cell chronic lymphocytic leukemia
lcsh:Science (General)
Aged
Neoplasm Staging
business.industry
lcsh:R
Advanced stage
ADP-ribosyl Cyclase 1
Leukemia
Lymphocytic
Chronic
B-Cell
Cross-Sectional Studies
030104 developmental biology
lcsh:Biology (General)
Rai
Splenomegaly
business
lcsh:Q1-390
Zdroj: BMC Research Notes
BMC Research Notes, Vol 12, Iss 1, Pp 1-6 (2019)
ISSN: 1756-0500
Popis: Objective To investigate the ZAP-70 and CD38 expressions and their combined expressions in Sudanese B-CLL patients and their relationships with clinical and hematological characteristics as well as the disease staging at presentation. Results In the present cross-sectional descriptive study, analysis of ZAP-70 expression showed that 36/110 (32.7%) patients positively expressed ZAP-70 and insignificant higher presentation in intermediate and at advanced stages as well as no correlation was seen with hematological parameters and clinical features compared with negatively ZAP-70, on the other hand, 41/110 (37.3%) were CD38+ and no significant correlation was shown with the stage at presentation, clinical characteristics (except Splenomegaly, P = 0.02) and hematological parameters. However, in combined expressions of both ZAP-70 and CD38 together, 20/110 (18.2%) were concordantly ZAP-70+/CD38+, 53/110 (48.2%) concordantly ZAP-70−/CD38− and 37/110 (33.6%) either ZAP-70+ or CD38+, and these three groups showed insignificant correlation with clinical (except Splenomegaly, P = 0.03) and hematological parameters, and the stage at presentation. Our data showed the combined analysis of these two markers, lead to classify our patients into three subgroups (either concordant positive, negative or discordant expressions) with statistically insignificant correlation with clinical presentation (except Splenomegaly), hematological parameters and stage at presentation of B-CLL patients. Electronic supplementary material The online version of this article (10.1186/s13104-019-4319-8) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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