Influence of dystrophin-gene mutation onmdx mouse behavior. I. Retention deficits at long delays in spontaneous alternation and bar-pressing tasks
| Autor: | René Misslin, Arielle Ungerer, Cyrille Vaillend, Alvaro Rendon |
|---|---|
| Přispěvatelé: | Neurobiologie de l'apprentissage, de la mémoire et de la communication (NAMC), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Ethologie et de Neurobiologie, URA CNRS 1295, Université Louis Pasteur - Strasbourg I |
| Rok vydání: | 1995 |
| Předmět: |
Male
mdx mouse [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Duchenne muscular dystrophy MESH: Mental Recall medicine.disease_cause MESH: Muscular Dystrophy Animal MESH: Synapses Dystrophin Mice 0302 clinical medicine MESH: Animals Genetics (clinical) 0303 health sciences Mutation [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior biology MESH: Mice Inbred mdx Retention Psychology [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences Cognition Spontaneous alternation musculoskeletal system MESH: Motor Activity Motor coordination Motor Skills MESH: Exploratory Behavior Arousal Psychology musculoskeletal diseases congenital hereditary and neonatal diseases and abnormalities MESH: Space Perception Motor Activity 03 medical and health sciences MESH: Dystrophin MESH: Mice Inbred C57BL Reaction Time Genetics medicine Animals Maze Learning MESH: Mice Ecology Evolution Behavior and Systematics 030304 developmental biology MESH: Arousal MESH: Maze Learning MESH: Retention Psychology Muscular Dystrophy Animal medicine.disease Dystrophin gene MESH: Male MESH: Reaction Time Mice Inbred C57BL Mental Recall Exploratory Behavior Mice Inbred mdx biology.protein Neuroscience 030217 neurology & neurosurgery MESH: Motor Skills |
| Zdroj: | Behavior Genetics Behavior Genetics, Springer Verlag, 1995, 25 (6), pp.569-579. ⟨10.1007/bf02327580⟩ |
| ISSN: | 1573-3297 0001-8244 |
| DOI: | 10.1007/bf02327580 |
| Popis: | International audience; X-linked Duchenne muscular dystrophy (DMD) is frequently associated with a nonprogressive, cognitive defect attributed to the absence of dystrophin in the brain of DMD patients. The mutant mdx mouse, lacking in 427-kDa dystrophin in both muscle and brain tissues, is considered to be a valuable model of human DMD. In the present study, we compared mdx and C57BL/10 control mice and showed that mdx mice had impaired retention in a T-maze, delayed spontaneous alternation task 24 h, but not 6 h, after acquisition. mdx mice were not impaired in acquisition of a bar-pressing task on 4 consecutive days but showed poor retention 22 days after the last training session. Mutants and controls showed similar behavioral responses in free exploration and light/dark choice situations and did not differ in spontaneous locomotor activity or motor coordination. Retention impairments at long delays in mdx mice suggest a role of dystrophin in long-term consolidation processes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink