Elevated 1-hour postload plasma glucose levels identify subjects with normal glucose tolerance but impaired β-cell function, insulin resistance, and worse cardiovascular risk profile: the GENFIEV study
| Autor: | Bianchi, C, Miccoli, R, Trombetta, M, Giorgino, F, Frontoni, S, Faloia, E, Marchesini, G, Dolci, Ma, Cavalot, F, Cavallo, G, Leonetti, F, Bonadonna, Rc, Del Prato, S, on behalf of the GENFIEV Investigators, Trovati, Mariella |
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| Přispěvatelé: | Bianchi C, Miccoli R, Trombetta M, Giorgino F, Frontoni S, Faloia E, Marchesini Reggiani G, Dolci MA, Cavalot F, Cavallo G, Leonetti F, Bonadonna RC, Del Prato S, on behalf of the GENFIEV Investigators |
| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Male endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment disfunction Clinical Biochemistry NGT OGTT type 2 diabetes Type 2 diabetes Biochemistry Body Mass Index Impaired glucose tolerance Endocrinology Insulin-Secreting Cells Insulin Secretion type-2 diabetes mellitus sensitivity Insulin Glucose tolerance test medicine.diagnostic_test Middle Aged Impaired fasting glucose Italy Cardiovascular Diseases Prediabete Female Type 2 hormones hormone substitutes and hormone antagonists Adult Risk medicine.medical_specialty Beta-cell function Models Biological Prediabetic State Insulin resistance Diabetes mellitus Internal medicine Glucose Intolerance Diabetes Mellitus medicine Humans business.industry Biochemistry (medical) nutritional and metabolic diseases Settore MED/13 - ENDOCRINOLOGIA Glucose Tolerance Test Overweight medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 2 Insulin Resistance Lipid profile business |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 98(5) |
| ISSN: | 1945-7197 |
| Popis: | Context: In subjects with normal glucose tolerance (NGT) 1-hour postload plasma glucose (1-h oral glucose tolerance test [OGTT]) of 155 mg/dL predicts type 2 diabetes (T2DM) and is associated with subclinical atherosclerosis. Objective: The purpose of this study was to evaluate -cell function, insulin resistance, and cardiovascular risk profile in subjects with NGT with a 1-h OGTT glucose of 155 mg/dL. Patients and Methods: The GENFIEV (Genetics, PHYsiopathology, and Evolution of Type 2 diabetes) study is a multicenter study recruiting individuals at high risk of T2DM. A total of 926 subjects underwent a 75-g OGTT for assessment of plasma glucose and C-peptide for mathematical modeling of beta-cell function (derivative and proportional control). Fasting insulin, lipid profile, and clinical parameters were determined as well. Results: A 1-hour OGTT glucose of 155 mg/dL was found in 39% of subjects with NGT, 76% with impaired fasting glucose (IFG), 90% with impaired glucose tolerance (IGT), and 99% and 98% with IFG IGT or newly diagnosed T2DM, respectively. Among subjects with NGT (n=474), those with 1-hour OGTTglucose of155 mg/dL were more insulin-resistant and had worse beta-cell function than those with 1-hour OGTT glucose of 155 mg/dL. Moreover, glycosylated hemoglobin, blood pressure, low-density lipoprotein cholesterol, and triglycerides were higher in subjects with NGT with 1-hour OGTT glucose of155 mg/dL, whereas high-density lipoprotein cholesterol was lower compared with that in subjects with NGT with 1-hour OGTT glucose of 155 mg/dL. Compared with subjects with IGT, those with NGT with 1-hour OGTT glucose of 155 mg/dL had comparable cardiovascular risk profile and insulin resistance but slightly better beta-cell function. Conclusions: Among subjects with NGT, those with 1-hour OGTT glucose of 155 mg/dL showed lower insulin sensitivity, impaired beta-cell function, and worse cardiovascular risk profile and therefore are at greater risk of developing T2DM and cardiovascular disease. |
| Databáze: | OpenAIRE |
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