Isolated gestational proteinuria preceding the diagnosis of preeclampsia - an observational study
| Autor: | Shun Yasuda, Mana Obata-Yasuoka, Chihiro Hirai, Soromon Kataoka, Yosuke Baba, Hisanori Minakami, Akihito Nakai, Yoshiki Kudo, Shiori Minakawa, Yusuke Inde, Nao Murabayashi, Takeshi Umazume, Norimasa Sagawa, Makoto Maeda, Atsuo Itakura, Takahiro Yamada, Kosuke Kawabata, Akihide Ohkuchi, Hideto Kusaka, Yasumasa Ohno, Michikazu Nagura, Tomoaki Ikeda, Hiromi Hamada, Keiya Fujimori |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Gestational hypertension medicine.medical_specialty Adolescent Preeclampsia preeclampsia Young Adult 03 medical and health sciences 0302 clinical medicine Japan Pre-Eclampsia Pregnancy Risk Factors medicine Humans Disease pregnancy Clinical significance 030212 general & internal medicine Risk factor Retrospective Studies pregnancy outcome 030219 obstetrics & reproductive medicine Proteinuria Obstetrics business.industry Obstetrics and Gynecology Hypertension Pregnancy-Induced General Medicine Middle Aged medicine.disease proteinuria pregnancy Pregnancy Complications Creatinine Relative risk protein to creatinine ratio Female Observational study medicine.symptom business Maternal Age |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 95:1048-1054 |
| ISSN: | 0001-6349 |
| Popis: | Introduction Some pregnant women develop significant proteinuria in the absence of hypertension. However, clinical significance of isolated gestational proteinuria (IGP) is not well understood. This study aimed to determine the prevalence of IGP in singleton pregnancies and the proportion of women with IGP who subsequently developed preeclampsia (IGP-PE) among all PE cases. Material and methods This was an observational study of 6819 women with singleton pregnancies at 12 centers, including 938 women with at least once determination of protein-to-creatinine ratio (P/Cr). Significant proteinuria in pregnancy (SPIP) was defined as P/Cr (mg/mg) level >0.27. IGP was defined as SPIP in the absence of hypertension. Gestational hypertension (GH) preceding preeclampsia (GH-PE) was defined as preeclampsia (PE) in which GH preceded SPIP. Simultaneous PE (S-PE) was defined as PE in which both SPIP and hypertension occurred simultaneously. Results IGP and PE were diagnosed in 130 (1.9%) and 158 (2.3%) of 6819 women, respectively. Of 130 women with IGP, 32 (25%) progressed to PE and accounted for 20% of all women with PE. Hence, women with IGP had a relative risk of 13.1 (95% CI; 9.2–18.5) for developing PE compared with those without IGP [25% (32/130) vs. 1.9% (126/6689)]. At diagnosis of SPIP, P/Cr levels already exceeded 1.0 more often in women with S-PE than in those with IGP-PE [67% (33/49) vs. 44% (14/32), respectively, p = 0.031]. Conclusions IGP is a risk factor for PE, and IGP-PE accounts for a considerable proportion (20%) of all PE. |
| Databáze: | OpenAIRE |
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