TiO(2)-Capped Gold Nanorods for Plasmon-Enhanced Production of Reactive Oxygen Species and Photothermal Delivery of Chemotherapeutic Agents
| Autor: | Jennifer N. Cha, Liangcan He, Albert Harguindey, Chenchen Mao, Andrew P. Goodwin, Michael Brasino, Wounjhang Park |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Materials science
Nanostructure Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Article chemistry.chemical_compound Cell Line Tumor Humans General Materials Science Photosensitizer Surface plasmon resonance Plasmon Titanium Nanotubes Singlet oxygen technology industry and agriculture Photothermal therapy 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Doxorubicin Drug delivery Nanorod Gold 0210 nano-technology Reactive Oxygen Species |
| Popis: | Near infrared (NIR)-absorbing noble metal nanostructures are being extensively studied as theranostic agents, in particular for photoacoustic imaging and photothermal therapy. Because of the electric field enhancement at the tips of anisotropic metal nanostructures, positioning photoactive species at these sites can lead to increased energy absorption. Herein, we show the site-specific placement of NIR-active photosensitizers at the ends of gold nanorods (AuNRs) by growing porous TiO(2) caps. The surface plasmon resonance of the AuNRs was carefully tuned to overlap with the exciton absorption of indocyanine green (ICG), a NIR photosensitizer with low quantum yields and poor photostability. In conjugating high amounts of ICG to the TiO(2) caps, increased amounts of singlet oxygen ((1)O(2)) were generated as compared to when ICG was attached to sidewalls of the AuNRs. Because the AuNRs also cause local increases in temperature upon NIR excitation, DNA strands were next attached to the AuNRs sidewalls and loaded with doxorubicin (DOX). We found that the synergistic effect of increased (1)O(2) and photothermal-induced drug delivery led to significant improvements in tumor cell killing. This work demonstrates that with careful design over hybrid nanostructure synthesis, higher levels of tumor therapy may be achieved. |
| Databáze: | OpenAIRE |
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