Acute hemorrhagic leukoencephalitis of Weston Hurst secondary to herpes encephalitis presenting as status epilepticus: A case report and review of literature
| Autor: | Mark Willy L. Mondia, Adrian I. Espiritu, Jose Leonard R. Pascual, Nikolai Gil D. Reyes |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Fulminant Acyclovir Status epilepticus Antiviral Agents Methylprednisolone Gastroenterology Diagnosis Differential 03 medical and health sciences Status Epilepticus 0302 clinical medicine Physiology (medical) Internal medicine medicine Humans Leukocytosis Pleocytosis Intracerebral hemorrhage Coma business.industry General Medicine Middle Aged medicine.disease Leukoencephalitis Acute Hemorrhagic Neuroprotective Agents Neurology 030220 oncology & carcinogenesis Surgery Encephalitis Herpes Simplex Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Encephalitis medicine.drug |
| Zdroj: | Journal of Clinical Neuroscience. 67:265-270 |
| ISSN: | 0967-5868 |
| DOI: | 10.1016/j.jocn.2019.06.020 |
| Popis: | Acute hemorrhagic leukoencephalitis (AHL) is a rare and mostly fatal fulminant demyelinating disease. This case describes a 63-year old male in status epilepticus associated with an intracerebral hemorrhage following a one week viral prodrome with rapid decline to coma. He exhibited peripheral leukocytosis, neutrophilic pleocytosis with normal glucose and high protein in cerebrospinal fluid (CSF). Additionally, CSF was positive for herpes simplex virus (HSV) polymerase chain reaction (PCR). Medical decompression, low-dose dexamethasone, antibiotics and acyclovir were initially given. Magnetic resonance imaging (MRI) was suggestive of AHL, thus he was treated with methylprednisolone 1 g/day for 5 days. The patient improved and was discharged with significant neurologic morbidity. This is the first reported case of AHL in the Philippines presenting as a diagnostic dilemma with a protracted clinical course who responded to high dose intravenous steroids. |
| Databáze: | OpenAIRE |
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