The long-term residual effects of low-magnitude mechanical stimulation therapy on skeletal health

Autor: Richard T. Hart, Brooke Stephens, Kyle S. Kuchynsky, Kyle Bodnyk, Megan Balgemann
Rok vydání: 2020
Předmět:
Zdroj: Journal of Biological Engineering
Journal of Biological Engineering, Vol 14, Iss 1, Pp 1-14 (2020)
ISSN: 1754-1611
DOI: 10.1186/s13036-020-0232-x
Popis: Background Low-magnitude mechanical stimulation (LMMS) may improve skeletal health. The objective of this research was to investigate the long-term residual effects of LMMS on bone health. 10-week old female mice were given LMMS for 8 weeks; SHAM did not receive LMMS. Some groups remained on study for an additional 8 or 16 weeks post treatment (N = 17). Results Epiphyseal trabecular mineralizing surface to bone surface ratio (MS/BS) and bone formation rate (BFR/BS) were significantly greater in the LMMS group compared to the SHAM group at 8 weeks by 92 and 128% respectively. Mineral apposition rate (MAR) was significantly greater in the LMMS group 16 weeks post treatment by 14%. Metaphyseal trabecular bone mineral density (BMD) increased by 18%, bone volume tissue volume ratio (BV/TV) increased by 37%, and trabecular thickness (Tb.Th.) increased by 10% with LMMS at 8 weeks post treatment. Significant effects 16 weeks post treatment were maintained for BV/TV and Tb.Th. The middle-cortical region bone volume (BV) increased by 4% and cortical thickness increased by 3% with 8-week LMMS. Conclusions LMMS improves bone morphological parameters immediately after and in some cases long-term post LMMS. Results from this work will be helpful in developing treatment strategies to increase bone health in younger individuals.
Databáze: OpenAIRE
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