House dust endotoxin, asthma and allergic sensitization through childhood into adolescence

Autor: Gehring, Ulrike, Wijga, Alet H, Koppelman, Gerard H, Vonk, Judith M, Smit, Henriëtte A, Brunekreef, Bert, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2
Přispěvatelé: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Groningen Research Institute for Asthma and COPD (GRIAC)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
endotoxin
Lipopolysaccharide Receptors
SCHOOL-CHILDREN
Allergic sensitization
MITE ALLERGEN
0302 clinical medicine
Interquartile range
Risk Factors
Prevalence
Immunology and Allergy
Medicine
Longitudinal Studies
Prospective Studies
Child
Sensitization
Netherlands
Inhalation Exposure
Single exposure
Age Factors
Dust
birth cohort
ASSOCIATION
medicine.anatomical_structure
ATOPIC SENSITIZATION
Child
Preschool
Original Article
Editor‐in‐Chief's Editorial: Epidemiology of Allergic Disease
Female
Birth cohort
medicine.medical_specialty
Adolescent
CD14/-260
Immunology
allergic sensitization
Polymorphism
Single Nucleotide
Risk Assessment
03 medical and health sciences
Internal medicine
Humans
lergic sensitization
Asthma
business.industry
Infant
Newborn
Infant
Odds ratio
Protective Factors
asthma
medicine.disease
PREVENTION
Confidence interval
respiratory tract diseases
Endotoxins
Toll-Like Receptor 4
HIGH-RISK
030104 developmental biology
MICROBIAL EXPOSURE
030228 respiratory system
MOLD COMPONENTS
ORIGINAL ARTICLES
business
Zdroj: Clinical and Experimental Allergy
Clinical and Experimental Allergy, 50(9), 1-10. Wiley
Clinical and Experimental Allergy, 50(9), 1055. Blackwell Publishing Ltd
ISSN: 0954-7894
Popis: Background: House dust endotoxin may have beneficial effects on allergic sensitization and asthma in children. Evidence is scarce for adolescents and most studies so far have been cross-sectional and limited to a single exposure measurement. Objective: We assessed associations of house dust endotoxin with asthma and allergic sensitization from birth to age 17 years longitudinally taking into account exposure early in life and at primary school age. Methods: We used data of 854 participants of the prospective Dutch PIAMA birth cohort study with house dust endotoxin measurements at 3 months and/or 5-6 years and data on asthma and/or allergic sensitization from at least one of 11 follow-ups until age 17. We assessed overall and age-specific associations of the prevalence of asthma and sensitization with mattress and living room floor dust concentrations (per gram of dust) and loads (per m2 of sampling surface). Results: Higher living room floor dust endotoxin concentrations at 3 months were associated with lower odds of asthma until age 4 [odds ratio (95% confidence interval) ranging from 0.70 (0.51-0.97) at age 1 to 0.76 (0.57-1.00) at age 3 per interquartile range increase], but not thereafter in children of allergic mothers. Higher living room floor dust endotoxin at 5-6 years was associated with higher odds of sensitization at 8-16 years [eg odds ratio (95% confidence interval) 1.70 (1.17-2.47) per interquartile range increase in endotoxin load]. Conclusions and clinical relevance: House dust endotoxin may have beneficial effects on asthma in preschool children of allergic mothers, which do not persist into adolescence. Beneficial associations with allergic sensitization could not be confirmed.
Databáze: OpenAIRE
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