Treatment and outcome in cancer cervix patients treated between 1979 and 1994: A single institutional experience

Autor: Umesh Mahantshetty, Shyamkishore Shrivastava, Reena Engineer, Hemant Tongaonkar, Jagadeesh Kulkarni, Ketayun Dinshaw
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Adult
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Brachytherapy
Uterine Cervical Neoplasms
Cervix Uteri
Adenocarcinoma
lcsh:RC254-282
Disease-Free Survival
Young Adult
international federation of gynecology and obstetrics stage
medicine
Carcinoma
Humans
Radiology
Nuclear Medicine and imaging
Young adult
Radical surgery
Stage (cooking)
Cervix
Aged
Neoplasm Staging
Retrospective Studies
Aged
80 and over
business.industry
Cancer
Retrospective cohort study
Radiotherapy Dosage
General Medicine
Cancer cervix
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Surgery
Radiation therapy
medicine.anatomical_structure
Treatment Outcome
radical radiation therapy
Oncology
Carcinoma
Squamous Cell
pre-operative radiation
Female
business
late sequelae
Zdroj: Journal of Cancer Research and Therapeutics, Vol 9, Iss 4, Pp 672-679 (2013)
ISSN: 1998-4138
0973-1482
Popis: Introduction: A retrospective review in patients with carcinoma cervix to evaluate the changes and trends in demographics, evolution of protocols, and outcome analysis over 16 years. Materials and Methods: This is a retrospective study of 6234 patients with carcinoma of the cervix treated with radical intent between 1979 and 1994. All the work-up, staging investigations, treatment details, radiation protocols, outcomes, and toxicities were noted, compiled, and analyzed. Results: With a mean age of 46 years (range: 18-90 years; median: 45 years), 669 (11%) patients were in stage Ib, 284 (5%) were in stage IIa, 1891 (30%) were in stage IIb, 69 (1%) were in stage IIIa, and 3321 (53%) were in stage IIIb. With a median follow-up of 68 months (57-79 months) for the entire group, there was no significant difference in the outcome of 953 patients with international federation of gynecology and obstetrics (FIGO) Ib-IIa treated after radical surgery, pre-operative radiation therapy (pre-op RT) + Sx or after radical radiation; their disease-free survival (DFS) was 60-62% at 8 years. In our series of 1891 patients with stage IIb and 3321 with stage IIIb, a respective DFS of 56% and 40% was achieved at 8 years. Conclusion: Over the last two decades, with the acquisition of newer facilities and inception of Joint Clinics, there has been a significant refinement in the treatment protocols and outcome. Improving radiation strategies to improve therapeutic ratio is the key to success.
Databáze: OpenAIRE
Externí odkaz: