Transmission and prevalence of drug-resistant tuberculosis in a Brazilian setting under a directly observed therapy short-course strategy
Autor: | Vera Simonsen, Lucilaine Ferrazoli, Fábio Oliveira Latrilha, Angela Pires Brandão, Vera Maria Neder Galesi, Eliseu Alves Waldman, Juliana Maira Watanabe Pinhata |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Tuberculosis Adolescent Cross-sectional study Short Communication 030106 microbiology 030231 tropical medicine RC955-962 GUARULHOS (SP) Drug resistance Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Arctic medicine. Tropical medicine Tuberculosis Multidrug-Resistant Epidemiology Prevalence Humans Medicine Transmission Short course Young adult Directly Observed Therapy Directly observed treatment business.industry Mycobacterium tuberculosis medicine.disease Cross-Sectional Studies Infectious Diseases Female Parasitology RFLP Restriction fragment length polymorphism business Polymorphism Restriction Fragment Length Brazil |
Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical, Vol 53 (2020) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Revista da Sociedade Brasileira de Medicina Tropical |
ISSN: | 1678-9849 |
Popis: | INTRODUCTION: We aimed to estimate the prevalence and transmission of drug-resistant tuberculosis in a high-burden Brazilian setting under directly observed therapy short-course strategy. METHODS: Isolates of culture-confirmed pulmonary tuberculosis patients from Guarulhos, Brazil, diagnosed in October 2007-2011 were subjected to drug susceptibility and IS6110-restriction fragment length polymorphism testing. RESULTS: The overall resistance prevalence was 11.5% and the multi-drug resistance rate was 4.2%. Twenty-six (43.3%) of 60 drug-resistant isolates were clustered. Epidemiological relationships were identified in 11 (42.3%) patients; 30.8% of the cases were transmitted in households. CONCLUSIONS: Drug-resistant tuberculosis was relatively low and transmitted in households and the community. |
Databáze: | OpenAIRE |
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