A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline
| Autor: | L M McMurry, Stuart B. Levy, Dwight C. Hirsh, Lori M. Hansen |
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| Rok vydání: | 1993 |
| Předmět: |
Turkeys
Pasteurella multocida Tetracycline Molecular Sequence Data Microbiology Plasmid Escherichia coli medicine Animals Pharmacology (medical) Amino Acid Sequence Cloning Molecular Gene Antibacterial agent Pharmacology Genetics Base Sequence biology Structural gene Tetracycline Resistance Nucleic acid sequence Nucleic Acid Hybridization DNA biology.organism_classification Infectious Diseases Efflux Plasmids Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 37:2699-2705 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.37.12.2699 |
| Popis: | The tetracycline resistance determinant on plasmid pVM111 from an avian strain of Pasteurella multocida mediates tetracycline resistance by a regulated active efflux mechanism. DNA coding for the determinant did not hybridize at high stringency with DNA representing a group of common tetracycline resistance determinants. The DNA sequence, however; revealed a structural gene and a repressor gene which had significant (37 to 64%) sequence similarities with previously described classes of efflux-type tetracycline resistance genes from members of the family Enterobacteriaceae. The new determinant has been assigned to class H. |
| Databáze: | OpenAIRE |
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