Neurotrophic Effects of Magnesium Fructose 1, 6-Diphosphate on Cortical Neurons
| Autor: | Ruo-Hua Lv, Min-Jing Liao, Huan-Min Luo, Xiao-Yan Xue, Lian-Feng Lin, Fei Xiao |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Cell Survival Neurogenesis chemistry.chemical_element Dendrite Ciliary neurotrophic factor chemistry.chemical_compound Neurotrophic factors Internal medicine Fructosediphosphates medicine Glial cell line-derived neurotrophic factor Animals Magnesium Cerebral Cortex Neurons biology General Neuroscience Fructose Dendrites General Medicine Rats Endocrinology medicine.anatomical_structure Animals Newborn nervous system chemistry biology.protein Microtubule-Associated Proteins Adenosine triphosphate Neurotrophin |
| Zdroj: | International Journal of Neuroscience. 122:248-254 |
| ISSN: | 1543-5245 0020-7454 |
| DOI: | 10.3109/00207454.2011.648291 |
| Popis: | In this study, we evaluated the neurotrophic effects of magnesium fructose 1, 6-diphosphate (FDP-Mg) on cortical neurons. The results demonstrated that FDP-Mg promoted dendrite outgrowth and neuronal survival in a dose-dependent manner. In order to investigate the associated mechanisms, we determined adenosine triphosphate (ATP) levels and brain-derived neurotrophic factor (BDNF) mRNA expression in cortical neurons. Treatment with FDP-Mg significantly increased ATP levels and BDNF mRNA expression in cortical neurons. These data suggest that FDP-Mg can exert neurotrophic effects on cortical neurons. The increases in BDNF mRNA expression and cellular ATP levels are involved in the neurotrophic effects produced by FDP-Mg. |
| Databáze: | OpenAIRE |
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