Diagnostic Performance of a Panel of miRNAs (OsteomiR) for Osteoporosis in a Cohort of Postmenopausal Women
| Autor: | Ursula Föger-Samwald, Katharina Kerschan-Schindl, Peter Pietschmann, Johannes Grillari, E. Boschitsch, O. Nägele, Moritz Weigl, Susanna Skalicky, Matthias Hackl |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Fragility fracture: circulating microRNA Endocrinology Diabetes and Metabolism Osteoporosis Postmenopausal osteoporosis Logistic regression 03 medical and health sciences 0302 clinical medicine Endocrinology Bone Density Internal medicine medicine Humans Orthopedics and Sports Medicine Osteoporosis Postmenopausal Original Research Postmenopausal women business.industry Serum samples medicine.disease Postmenopause osteomiR MicroRNAs 030104 developmental biology Cross-Sectional Studies Bone biomarker 030220 oncology & carcinogenesis Cohort Orthopedic surgery Who criteria Female business Osteoporotic Fractures |
| Zdroj: | Calcified Tissue International |
| ISSN: | 1432-0827 |
| Popis: | A specific signature of 19 circulating miRNAs (osteomiRs) has been reported to be associated with fragility fractures due to postmenopausal osteoporosis. However, it is unknown whether osteoporotic fractures or low BMD phenotypes are independently contributing to changes in osteomiR serum levels. The first aim was to characterize the abundance, sensitivity to hemolysis, and correlation of osteomiR serum levels, the second objective to evaluate the diagnostic accuracy of osteomiRs for osteoporosis according to the WHO criteria and on basis of major osteoporotic fracture history. Fifty postmenopausal women with osteoporosis (with or without fragility fracture) and 50 non-osteoporotic women were included in this cross-sectional study. The diagnostic performance of osteomiRs for osteoporosis based on the WHO definition or fracture history was evaluated using multiple logistic regression and receiver-operator curve (AUC) analysis. The osteomiR® signature is composed of four clusters of miRNAs providing good performance for the diagnosis of osteoporosis in postmenopausal women defined by WHO criteria (AUC = 0.830) and based on history of major osteoporotic fractures (AUC = 0.834). The classification performance for the WHO criteria and for fracture risk is driven by miR-375 and miR-203a, respectively. OsteomiRs, a signature of 19 emerging miRNA bone biomarkers, are measurable in human serum samples. They constitute a panel of independent bone and muscle biomarkers, which in combination could serve as diagnostic biomarkers for osteoporosis in postmenopausal women. Supplementary Information The online version of this article (doi:10.1007/s00223-020-00802-3) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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