Emerging Therapies Targeting Tumor Vasculature in Multiple Myeloma and other Hematologic and Solid Malignancies
| Autor: | Klaus Podar, K C Anderson |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Niacinamide
Vascular Endothelial Growth Factor A Sorafenib Cancer Research Indoles Pyridines Angiogenesis Angiogenesis Inhibitors Pharmacology Neovascularization Pazopanib chemistry.chemical_compound Drug Discovery Sunitinib medicine Humans Pyrroles Protein Kinase Inhibitors Wnt Signaling Pathway Multiple myeloma Neovascularization Pathologic business.industry Phenylurea Compounds Benzenesulfonates Antibodies Monoclonal Cancer Protein-Tyrosine Kinases medicine.disease Thalidomide Vascular endothelial growth factor Receptors Vascular Endothelial Growth Factor Oncology chemistry Hematologic Neoplasms Cancer research Phthalazines medicine.symptom Multiple Myeloma business Signal Transduction medicine.drug |
| Zdroj: | Current Cancer Drug Targets. 11:1005-1024 |
| ISSN: | 1568-0096 |
| DOI: | 10.2174/156800911798073113 |
| Popis: | Research on the formation of new blood vessels (angiogenesis) in general and vascular endothelial growth factor (VEGF) in particular is a major focus in biomedicine and has led to the clinical approval of the monoclonal anti- VEGF antibody bevazicumab; and the second-generation multitargeted receptor kinase inhibitors (RTKIs) sorafenib, sunitinib, and pazopanib. Although these agents show significant preclinical and clinical anti-cancer activity, they prolong overall survival of cancer patients for only months, followed by a restoration of tumor growth and progression. Therefore, there is a clear need to increase our understanding of tumor angiogenesis and the development of resistance. In this review we discuss up-to-date knowledge on mechanisms of tumor angiogenesis, and summarize preclinical and clinical data on existing and potential future anti-angiogenic agents and treatment strategies for Multiple Myeloma (MM) and other hematologic and solid malignancies. |
| Databáze: | OpenAIRE |
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