A Practical Total Synthesis of Globo-H for Use in Anticancer Vaccines

Autor:	Karthik Iyer, Samuel J. Danishefsky, Insik Jeon
Rok vydání:	2009
Předmět:	Carbohydrate Sequence Biochemistry Antigen Chemistry Molecular Sequence Data Organic Chemistry Total synthesis Antigens Tumor-Associated Carbohydrate Key features Cancer Vaccines Combinatorial chemistry Article
Zdroj:	The Journal of Organic Chemistry. 74:8452-8455
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo901682p
Popis:	An improved synthesis of the hexasaccharide MBr1 antigen (globo-H) is reported. Enhanced efficiency in the synthesis was necessary for the scale-up production of globo-H, in order to advance globo-H-based anticancer vaccines to clinical trials. The key features of the improved synthesis include preactivation-based glycosylations and a revised iodosulfonimidation/rearrangement.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ade60a6bf6cc9a9b3fcaf543533ee2 https://doi.org/10.1021/jo901682p Zobrazit plný text záznamu