Natural Course of Mild Graves Orbitopathy: Increase of Orbital Fat But Decrease of Muscle Volume With Increased Muscle Fatty Degeneration During a 4-Year Follow-Up
| Autor: | Wilmar M. Wiersinga, Maarten P. Mourits, Maartje M.L. de Win, Peter W. Potgieser |
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| Přispěvatelé: | Ophthalmology, Radiology and Nuclear Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology Oculomotor Muscles/pathology Degeneration (medical) Muscle volume Extraocular muscles Orbital fat Medicine Humans In patient Tomography Natural course business.industry General Medicine Middle Aged Adipose Tissue/pathology eye diseases X-Ray Computed Graves Ophthalmopathy/pathology Graves Ophthalmopathy Ophthalmology medicine.anatomical_structure Adipose Tissue Oculomotor Muscles Surgery Female Orbit/pathology Intramuscular fat Eyelid business Tomography X-Ray Computed Orbit Follow-Up Studies |
| Zdroj: | Ophthalmic plastic and reconstructive surgery, 35(5), 456-460. Lippincott Williams and Wilkins |
| ISSN: | 0740-9303 |
| Popis: | Purpose To describe the natural course of orbital fat volume and extraocular muscle volume in mild Graves orbitopathy during a 4-year follow-up. To describe fatty changes within the extraocular muscles. Patients Twenty-five patients with mild Graves orbitopathy, who did not require any therapeutic intervention other than supportive therapy, were followed for 4 years. Methods CT scans were performed in all patients at baseline and follow-up. A validated technique using Mimics (Materialise) was used to calculate fat and muscle volumes. Outcomes were compared with previously collected data. The amount of intramuscular fat was assessed on CT scans in a semi-quantitative way by two blinded observers according to a four-point scale. Results After a median follow-up of 4.3 years, the median fat to orbital volume ratio increased with 0.08 from 0.57 to 0.65 (p = 0.000), whereas the median muscle volume to orbital volume ratio decreased with 0.03 from 0.17 to 0.14 (p = 0.000). In this control group in patients between 49 and 54 years old, the changes were 0.01 and -0.002, respectively. The Clinical Activity Score decreased to zero (p = 0.000), and the median eyelid aperture decreased from 12 to 10 mm (p = 0.007). A significant increase of intramuscular fat was found in patients with Graves orbitopathy. Conclusions The natural course of mild Graves orbitopathy, as observed over 4 years, is characterized by an increase of orbital fat volume, a decrease in muscle volume, and an increased intramuscular fatty degeneration. |
| Databáze: | OpenAIRE |
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