Evaluation of the Neurological Safety of Epidural Milnacipran in Rats
| Autor: | Young Jin Lim, Francis Sahngun Nahm, Seung Mo Lim, Hwa Yong Shin, Sang Chul Lee, Hyun Kang, Kyung Ho Kang, Baek Hui Kim, Mee Ran Shin |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
business.industry
medicine.drug_class medicine.medical_treatment Neurotoxicity medicine.disease Spinal cord milnacipran Anesthesiology and Pain Medicine medicine.anatomical_structure epidural injection Milnacipran Anesthesia neurotoxicity Neuropathic pain Medicine Original Article Animal studies Epidural administration business Saline medicine.drug Serotonin–norepinephrine reuptake inhibitor |
| Zdroj: | The Korean Journal of Pain |
| ISSN: | 2093-0569 2005-9159 |
| Popis: | Background: Milnacipran is a balanced serotonin norepinephrine reuptake inhibitor with minimal side effects and broad safety margin. It acts primarily on the descending inhibitory pain pathway in brain and spinal cord. In many animal studies, intrathecal administration of milnacipran is effective in neuropathic pain management. However, there is no study for the neurological safety of milnacipran when it is administered neuraxially. This study examined the neurotoxicity of epidural milnacipran by observing behavioral and sensory-motor changes with histopathological examinations of spinal cords in rats. Methods: Sixty rats were divided into 3 groups, with each group receiving epidural administration of either 0.3 ml (3 mg) of milnacipran (group M, n = 20), 0.3 ml of 40% alcohol (group A, n = 20), or 0.3 ml of normal saline (group S, n = 20). Results: There were no abnormal changes in the behavioral, sensory-motor, or histopathological findings in all rats of groups M and S over a 3-week observation period, whereas all rats in group A had abnormal changes. Conclusions: Based on these findings, the direct epidural administration of milnacipran in rats did not present any evidence of neurotoxicity in behavioral, sensory-motor and histopathological evaluations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|