Apolipoprotein E- 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV
| Autor: | David White, Ashini Jayasuriya, Ruth Noone, Matthew A. Wozniak, Gerry Gilleran, Erasmus Smit, Steve Taylor, Rajul Patel, Ruth F. Itzhaki |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Sexually transmitted disease Apolipoprotein E Herpesvirus 2 Human AIDS-Related Opportunistic Infections Apolipoprotein E4 Dermatology medicine.disease_cause Virus Herpesviridae Acquired immunodeficiency syndrome (AIDS) medicine Humans Genetic Predisposition to Disease Herpes Genitalis Alleles business.industry medicine.disease Virology Infectious Diseases Herpes simplex virus Immunology Female business |
| Zdroj: | Sexually Transmitted Infections. 84:516-517 |
| ISSN: | 1368-4973 |
| DOI: | 10.1136/sti.2008.032367 |
| Popis: | Apolipoprotein E (APOE) alleles have been associated with the severity of, or susceptibility to, infection by various microbes. We investigated the potential association between the APOE-epsilon 4 allele and the rate of recurrence of genital herpes in patients who were HIV positive and herpes simplex virus type 2 (HSV-2) seropositive. The APOE-epsilon 4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count (OR 8.3; 95% CI 2.4 to 28.5). To our knowledge, this is the first published study to demonstrate this association and suggests that APOE-epsilon 4 may represent a future prognostic marker for symptomatic recurrence of genital herpes in individuals with HIV. |
| Databáze: | OpenAIRE |
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