Presence of neuropathic pain may explain poor performances on olfactory testing in diabetes mellitus patients
| Autor: | Cory Toth, Shauna Brady, Alexandra Garven, Paul Lalli, Cynthia Chan, Ayechen Chan, Nisha Midha |
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| Rok vydání: | 2013 |
| Předmět: |
Olfactory system
Male medicine.medical_specialty Diabetic neuropathy Physiology Population Olfaction Behavioral Neuroscience Diabetic Neuropathies Physiology (medical) Internal medicine Diabetes mellitus medicine Humans education education.field_of_study business.industry Type 2 Diabetes Mellitus Middle Aged medicine.disease Sensory Systems Smell Peripheral neuropathy Diabetes Mellitus Type 2 Anesthesia Neuropathic pain Neuralgia Regression Analysis Female business |
| Zdroj: | Chemical senses. 38(6) |
| ISSN: | 1464-3553 |
| Popis: | Olfactory dysfunction in neurodegenerative conditions such as Parkinson's syndrome and Alzheimer's disease can hallmark disease onset. We hypothesized that patients with diabetes mellitus, a condition featuring peripheral and central neurodegeneration, would have decreased olfaction abilities. We examined participants with diabetic peripheral neuropathy, participants with diabetes without diabetic peripheral neuropathy, and control participants in blinded fashion using standardized Sniffin' Sticks. Diabetic peripheral neuropathy severity was quantified using the Utah Early Neuropathy Scale. Further subcategorization of diabetic peripheral neuropathy based on presence of neuropathic pain was performed with Douleur Neuropathique 4 Questionnaires. Participants with diabetes had decreased olfactory sensitivity, impaired olfactory discrimination abilities, and reduced odor identification skills when compared with controls. However, loss of olfaction ability was, at least partially, attributed to presence of neuropathic pain on subcategory assessment, although pain severity was not associated with dysfunction. Those participants with diabetes without diabetic peripheral neuropathy and those with diabetic peripheral neuropathy without neuropathic pain had similar olfactory function as controls in general. The presence of neuropathic pain, associated with limited attention and concentration, may explain at least a portion of the olfactory dysfunction witnessed in the diabetic patient population. |
| Databáze: | OpenAIRE |
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