In vivo suppression of benzene and styrene oxidation by co-administered toluene in rats and effects of phenobarbital
| Autor: | Toshiko Imamura, Hatsue Ohtsuji, Masayuki Ikeda |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Phenylglyoxylic acid
Health Toxicology and Mutagenesis Toxicology Biochemistry Medicinal chemistry Styrene Styrenes chemistry.chemical_compound medicine Organic chemistry Phenol Animals Drug Interactions Benzene Biotransformation Pharmacology Hippurates Hippuric acid Glyoxylates Rats Inbred Strains General Medicine Mandelic acid Toluene Rats Kinetics chemistry Phenobarbital Mandelic Acids Female Oxidation-Reduction medicine.drug |
| Zdroj: | Xenobiotica; the fate of foreign compounds in biological systems. 2(2) |
| ISSN: | 0049-8254 |
| Popis: | 1. Biotransformations of benzene to phenol, and styrene to phenylglyoxylic acid, mandelic acid and hippuric acid were suppressed by co-administration of toluene.2. This is due to competitive inhibition of the oxidation mechanisms involved in the metabolism of these compounds; the induction of oxidative activities in the liver, with phenobarbital, alleviated the suppression.3. Possible potentiation of toxicity of benzene and styrene by co-exposure to toluene is discussed herein. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|