Increased Incidence of Type 1 Diabetes during the COVID-19 Pandemic in Romanian Children
| Autor: | Viorel Serban, Bogdan Timar, Adrian Vlad, Veronica Botea, Mihaela Vlad, Romulus Timar, Oana Albai, Alexandra Sima |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Background information
Pediatrics medicine.medical_specialty Medicine (General) Coronavirus disease 2019 (COVID-19) Adolescent type 1 diabetes Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) medicine.disease_cause Article Autoimmunity R5-920 Diabetes mellitus Pandemic Medicine Humans Child Pandemics Type 1 diabetes business.industry Romania SARS-CoV-2 Incidence (epidemiology) Incidence COVID-19 General Medicine medicine.disease Diabetes Mellitus Type 1 business |
| Zdroj: | Medicina Medicina, Vol 57, Iss 973, p 973 (2021) Volume 57 Issue 9 |
| ISSN: | 1648-9144 1010-660X |
| Popis: | Background and Objective: It is known that several viruses are involved in the pathogenesis of type 1 diabetes. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new worldwide spread virus that may act as a trigger for the autoimmune destruction of the β-cells, as well, and thus lead to an increase in the incidence of type 1 diabetes. Material and Methods: The Romanian National Organization for the Protection of Children and Adolescents with Diabetes (ONROCAD) has collected information regarding new cases of type 1 diabetes in children aged 0 to 14 years from all over the country since 1996 and has computed the incidence of type 1 diabetes in this age group. Results: We observed a marked increase in the incidence of type 1 diabetes in the first year of the COVID-19 pandemic, with 16.9%, from 11.4/100,000 in 2019 to 13.3/100,000 in 2020, much higher compared to previous years (mean yearly increase was 5.1% in the period 1996–2015 and 0.8% in the interval 2015–2019). The proportion of newly diagnosed cases was significantly higher in the second half of 2020 compared to the second half of the previous years (57.8 vs. 51%, p < 0.0001). Conclusions: All these aspects suggest the role that SARS-CoV-2 could have in triggering pancreatic autoimmunity. To confirm this, however, collecting information from larger populations from different geographical regions, monitoring the incidence curves over a period of several years, and gathering background information on COVID-19 and/or data on COVID-19 specific antibodies are needed. |
| Databáze: | OpenAIRE |
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