Utility of frozen-section analysis of sentinel lymph node biopsy specimens for melanoma in surgical decision making
| Autor: | Mazin Al-Kasspooles, Ivan Damjanov, Casey P. Hertzenberg, Weesam Alkhatib, William R. Jewell, Mark S. Cohen |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms medicine.medical_treatment Decision Making Sentinel lymph node Article Diagnosis Differential Predictive Value of Tests Biopsy medicine Frozen Sections Humans False Negative Reactions Melanoma Lymph node Retrospective Studies Frozen section procedure medicine.diagnostic_test Sentinel Lymph Node Biopsy business.industry Reproducibility of Results General Medicine Middle Aged medicine.disease Surgery medicine.anatomical_structure Lymphatic Metastasis Cutaneous melanoma Female Lymphadenectomy Lymph Nodes Radiology Lymph business |
| Zdroj: | The American Journal of Surgery. 196:827-833 |
| ISSN: | 0002-9610 |
| DOI: | 10.1016/j.amjsurg.2008.07.034 |
| Popis: | Background Debate exists whether frozen-section analysis of sentinel lymph nodes (SLNs) for melanoma is an accurate method to detect disease that has metastasized to the lymph nodes. The purpose of this study was to evaluate the utility of intraoperative frozen section for SLNs in melanoma. Methods We reviewed 133 patients (271 nodes) who underwent SLN biopsy with frozen section for melanoma between April 2003 and September 2007. Frozen-section diagnosis was compared with final diagnosis to determine concordance between intraoperative and postsurgical diagnosis. Results A total of 11 nodes (8% of patients) were found to have metastatic disease. All patients underwent lymph node dissections at the time of SLN biopsy. No false-positive SLNs were found on frozen section. The false-negative rate for SLN biopsy frozen section was 8% (1 of 133 patients). Conclusions Intraoperative frozen section can be an accurate and reliable tool in the right setting for analysis of sentinel nodes in cutaneous melanoma and deserves further study. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect