Substance P receptors on human astrocytoma cells are linked to glycogen breakdown
| Autor: | Eric Gruenstein, Ruth V.W. Dimlich, Silvia Medrano |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Glycogenolysis Substance P Biology Astrocytoma chemistry.chemical_compound Norepinephrine Neurotransmitter receptor Internal medicine medicine Tumor Cells Cultured Humans Receptor Neurotransmitter Glycogen Dose-Response Relationship Drug Brain Neoplasms General Neuroscience Biphenyl Compounds Receptors Neurokinin-1 Drug Combinations Endocrinology medicine.anatomical_structure chemistry Histamine Astrocyte |
| Zdroj: | Neuroscience letters. 167(1-2) |
| ISSN: | 0304-3940 |
| Popis: | In this study we report that substance P stimulated [3H]glycogen breakdown and elevation of intracellular Ca2+ concentration in the human astrocytoma cell line UC-11MG. Both effects were dose dependent, and completely blocked by CP-96,345 suggesting the involvement of an NK1 receptor. Our previous studies indicated that norepinephrine and histamine stimulate glycogenolysis via cAMP and Ca2+ respectively. Combined stimulation with substance P and norepinephrine or histamine resulted in additive effects suggesting that there is no interaction between these neurotransmitters in regulating glycogenolysis in these cells. These results confirm that UC-11MG cells are a useful model system to investigate the functional role of neurotransmitter receptors in astroglial cells. |
| Databáze: | OpenAIRE |
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