Brown Adipose Tissue, Adiposity, and Metabolic Profile in Preschool Children
| Autor: | Cuilin Zhang, Yung Seng Lee, Kuan Jin Lee, Mya Thway Tint, Neerja Karnani, Marielle V. Fortier, Lynette Pei-Chi Shek, Shiao-Yng Chan, Chin Meng Khoo, Houchun H. Hu, Yap Seng Chong, Johan G. Eriksson, Navin Michael, S. Sendhil Velan, Fabian Yap, Keith M. Godfrey, Suresh Anand Sadananthan, Jonathan Y Huang, Ngee Lek, Melvin Khee-Shing Leow, Kok Hian Tan, Peter D. Gluckman |
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| Přispěvatelé: | Clinicum, Department of General Practice and Primary Health Care, HUS Helsinki and Uusimaa Hospital District |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Pediatric Obesity Endocrinology Diabetes and Metabolism Clinical Biochemistry Adipose tissue Biochemistry 030218 nuclear medicine & medical imaging Body Mass Index 0302 clinical medicine Endocrinology Adipose Tissue Brown Brown adipose tissue Medicine Mass index Prospective Studies Child 2. Zero hunger adiposity Singapore Fatty liver brown fat metabolic profile Magnetic Resonance Imaging medicine.anatomical_structure Liver Child Preschool Metabolome Female AcademicSubjects/MED00250 medicine.medical_specialty preschool children Abdominal Fat 030209 endocrinology & metabolism Context (language use) 03 medical and health sciences Asian People Metabolic Diseases Internal medicine Humans Muscle Skeletal Clinical Research Articles Soleus muscle business.industry Biochemistry (medical) medicine.disease Obesity 3121 General medicine internal medicine and other clinical medicine Metabolic syndrome Insulin Resistance business |
| Zdroj: | The Journal of Clinical Endocrinology and Metabolism |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Context An inverse relationship between brown adipose tissue (BAT) and obesity has previously been reported in older children and adults but is unknown in young children. Objective We investigated the influence of BAT in thermoneutral condition on adiposity and metabolic profile in Asian preschool children. Design, Setting, and Participants A total of 198 children aged 4.5 years from a prospective birth cohort study, Growing Up in Singapore Towards Healthy Outcomes (GUSTO) were successfully studied with water-fat magnetic resonance imaging of the supraclavicular and axillary fat depot (FDSA). Regions within FDSA with fat-signal-fraction between 20% and 80% were considered BAT, and percentage BAT (%BAT; 100*BAT volume/ FDSA volume) was calculated. Main Outcome Measures Abdominal adipose tissue compartment volumes, ectopic fat in the soleus muscle and liver, fatty liver index, metabolic syndrome scores, and markers of insulin sensitivity. Results A 1% unit increase in %BAT was associated with lower body mass index, difference (95% CI), −0.08 (−0.10, −0.06) kg/m2 and smaller abdominal adipose tissue compartment volumes. Ethnicity and sex modified these associations. In addition, each unit increase in %BAT was associated with lower ectopic fat at 4.5 years in the liver, −0.008% (−0.013%, −0.003%); soleus muscle, −0.003% (−0.006%, −0.001%) of water content and lower fatty liver index at 6 years. Conclusions Higher %BAT is associated with a more favorable metabolic profile. BAT may thus play a role in the pathophysiology of obesity and related metabolic disorders. The observed ethnic and sex differences imply that the protective effect of BAT may vary among different groups. |
| Databáze: | OpenAIRE |
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