Distinct Expression Patterns of CD123 and CD34 on Normal Bone Marrow B-Cell Precursors ('Hematogones') and B Lymphoblastic Leukemia Blasts
| Autor: | Felisa Alcancia, Patrick J. Buckley, Kathryn Perkinson, Anand S. Lagoo, Nagwa M. Hassanein |
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| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Precursor Cells B-Lymphoid Lymphoblast Interleukin-3 Receptor alpha Subunit CD34 Antigens CD34 General Medicine Biology medicine.disease Minimal residual disease Molecular biology medicine.anatomical_structure Bone Marrow Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Acute lymphocytic leukemia Leukocytes medicine Humans Interleukin-3 receptor Bone marrow Burkitt's lymphoma B cell |
| Zdroj: | American Journal of Clinical Pathology. 132:573-580 |
| ISSN: | 1943-7722 0002-9173 |
| Popis: | We compared the expression of CD123, the alpha chain of the interleukin-3 receptor, on normal B-cell precursors in bone marrow ("hematogones") from 75 specimens and on leukemic blasts in 45 newly diagnosed B-acute lymphoblastic leukemias (B-ALL) cases. We found that the less mature hematogones (dim CD45+) that express CD34 lack CD123 expression, whereas the more mature hematogones (moderate CD45+) lack CD34 but always express CD123. In contrast with this discordant pattern of CD34 and CD123 expression in hematogones, blasts in 41 (91%) of 45 cases of B-ALL showed concordant expression of the 2 antigens: 80% (36 of 45) cases expressed both antigens, whereas 11% (5 of 45) expressed neither. We found that these distinct patterns of CD34/CD123 expression on hematogones (discordant) and B-ALL blasts (concordant) remain stable after chemotherapy and are useful in differentiating small populations of residual blasts from hematogones that may be simultaneously present. |
| Databáze: | OpenAIRE |
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