Regional Pancreatic Concentration and In-vitro Secretion of Canine Pancreatic Polypeptide, Insulin, and Glucagon
| Autor: | Paul E. Lacy, Melvin G Johnson, Ronald L. Gingerich, Ronald E Chance |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.medical_specialty
Arginine Endocrinology Diabetes and Metabolism medicine.medical_treatment Radioimmunoassay Cross Reactions In Vitro Techniques Glucagon Dogs Internal medicine Insulin Secretion Internal Medicine medicine Animals Insulin Pancreatic polypeptide Secretion Pancreas Chemistry In vitro Kinetics medicine.anatomical_structure Endocrinology Bucladesine Peptides |
| Zdroj: | Diabetes. 27:96-101 |
| ISSN: | 1939-327X 0012-1797 |
| Popis: | The regional concentrations and in-vitro secretions of canine pancreatic polypeptide (cPP), insulin, and glucagon were studied. CPP is found predominantly in the uncinate process of the dog pancreas, whereas insulin and, more markedly, glucagon predominate in the body and taO of the pancreas. In-vitro secretion studies of pancreatic pieces indicate that dibutyryl cyclic AMP (dcAMP) alone can stimulate cPP release whereas glucose and arginine alone have no effect. Arginine, but not glucose, potentiates this stknulant effect of dcAMP. These studies suggest that the cAMP generating system may play a role in regulation of cPP secretion. |
| Databáze: | OpenAIRE |
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